ArticleEuropean journal of endocrinology2021
Abnormal body composition in patients with adrenal adenomas.
Article in European journal of endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Endocrinological aspects of sarcopenic obesity.Annals of medicine · 2026Review
- Association of Hormonal Activity with CT-Derived Body Composition Characteristics in Patients with Adrenal Adenomas.Journal of clinical medicine · 2026Article
- Comparison of bioimpedance and anthropometric estimates of body fat in patients with mild autonomous cortisol secretion and nonfunctional adrenal incidentalomas.Archives of endocrinology and metabolism · 2026Article
- Prognostic nutritional index and inflammatory indices as predictors of perioperative infection in patients with Cushing syndrome: a retrospective single-center study.Frontiers in endocrinology · 2026Article
- Assessment of aortic perivascular and renal sinus fat in endogenous cortisol excess of different etiology.Hormones (Athens, Greece) · 2025Article
- Relationship of obesity, body fat, benign adrenal tumors and the mediating mechanism: a two-step mendelian randomization study.BMC cancer · 2025Article
- Enhanced Chronic Inflammation and Increased Branched-Chain Amino Acids in Adrenal Disorders: A Cross-Sectional Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Steroid Profiling and Circadian Cortisol Secretion in Patients With Mild Autonomous Cortisol Secretion: A Cross-sectional Study.The Journal of clinical endocrinology and metabolism · 2025Article
- High LDL Particle and APOB Concentrations in Patients With Adrenal Cortical Adenomas.The Journal of clinical endocrinology and metabolism · 2024Article
- Cognition in patients with mild autonomous cortisol secretion at baseline and post-adrenalectomy.European journal of endocrinology · 2024Article
- Clinical Evaluation of Adrenal Incidentaloma: The Experience of a Referral Center.Biomedicines · 2024Article
- Kidney Function in Patients With Adrenal Adenomas: A Single-Center Retrospective Cohort Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches.Nature reviews. Endocrinology · 2024Review
- Diabetes Mellitus in Non-Functioning Adrenal Incidentalomas: Analysis of the Mild Autonomous Cortisol Secretion (MACS) Impact on Glucose Profile.Biomedicines · 2024Review
- Unique Gene Expression Signature in Periadrenal Adipose Tissue Identifies a High Blood Pressure Group in Patients With Cushing Syndrome.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Risk of dementia and psychiatric or sleep disorders after diagnosis of adrenal adenomas: a population-based cohort study.European journal of endocrinology · 2023Article
- High prevalence of frailty in patients with adrenal adenomas and adrenocortical hormone excess: a cross-sectional multi-centre study with prospective enrolment.European journal of endocrinology · 2023Article
- Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian population.Endocrine connections · 2022Article
- Subclinical Hypercortisolism: An Important, Unrecognized Dysfunction.Integrative medicine (Encinitas, Calif.) · 2022Article
- Pathophysiology of Mild Hypercortisolism: From the Bench to the Bedside.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveIncreased visceral fat and sarcopenia are cardiovascular risk factors that may explain increased cardiovascular morbidity and frailty in patients with adrenal adenomas. Our objective was to compare body composition measurement of patients with adrenal adenomas to referent subjects without adrenal disease.
designCross-sectional study, 2014-2018.
methodsParticipants were adults with nonfunctioning adrenal tumor (NFAT), mild autonomous cortisol secretion (MACS), and Cushing syndrome (CS) and age, sex, and BMI 1:1 matched referent subjects without adrenal disorders. Main outcome measures were body composition measurements calculated from abdominal CT imaging. Intra-abdominal adipose tissue and muscle mass measurements were performed at the third lumbar spine level.
resultsOf 227 patients with adrenal adenomas, 20 were diagnosed with CS, 76 with MACS, and 131 with NFAT. Median age was 56 years (range: 18-89), and 67% were women. When compared to referent subjects, patients with CS, MACS, and NFAT demonstrated a higher visceral fat (odds ratio (OR): 2.2 (95% CI: 0.9-6.5), 2.0 (1.3-3.2), and 1.8 (1.2-2.7) and a lower skeletal muscle area (OR: 0.01 (95% CI: 0-0.09), 0.31 (0.18-0.49), and 0.3 (1.2-2.7)) respectively. For every 1 µg/dL cortisol increase after overnight dexamethasone, visceral fat/muscle area ratio increased by 2.3 (P = 0.02) and mean total skeletal muscle area decreased by 2.2 cm2 (P = 0.03).
conclusionPatients with adrenal adenomas demonstrate a lower muscle mass and a higher proportion of visceral fat when compared to referent subjects, including patients with NFAT. Even a subtle abnormality in cortisol secretion may impact health of patients with adenomas.
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