Evidence map›Paper›PMID 34406839›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2021

Targeting Depressive Symptoms in Younger Breast Cancer Survivors: The Pathways to Wellness Randomized Controlled Trial of Mindfulness Meditation and Survivorship Education.

Julienne E Bower, Ann H Partridge, Antonio C Wolff, Elissa D Thorner, Michael R Irwin, Hadine Joffe, Laura Petersen, Catherine M Crespi, Patricia A Ganz

Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03025139 (Improving Outcomes for Younger Breast Cancer Survivors), which is not on this map. Cited by 51 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 11 pooled it
3.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03025139 naunknown statusnot on this map

Improving Outcomes for Younger Breast Cancer Survivors: A Phase III Randomized Trial Targeting Behavioral Symptoms in Younger Breast Cancer Survivors

TypeinterventionalSponsorJonsson Comprehensive Cancer CenterRan2017 to 2024Enrolled96ConditionsCancer Survivor, Early-Stage Breast Carcinoma, Stage 0 Breast Cancer, Stage IA Breast CancerArmsEducational Intervention, Laboratory Biomarker Analysis, Meditation Therapy, Questionnaire Administration
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 11 syntheses or guidelines pooled it, 68 citations in OpenAlex.

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  5. Psychosocial interventions to improve quality of life in Hispanic cancer survivors: a meta-analysis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025
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  7. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Julienne E BowerDepartment of Psychology, UCLA, Los Angeles, CA.ORCID 0000-0003-0813-4444
Ann H PartridgeMedical Oncology, Dana-Farber Cancer Institute, Boston, MA.ORCID 0000-0002-4722-4824
Antonio C WolffThe Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD.ORCID 0000-0003-3734-1063
Elissa D ThornerThe Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD.
Michael R IrwinDepartment of Psychology, UCLA, Los Angeles, CA.ORCID 0000-0002-1502-8431
Hadine JoffeConnors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Laura PetersenUCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA.
Catherine M CrespiUCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA.
Patricia A GanzUCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA.ORCID 0000-0002-1841-4143
Brigham and Women's Hospital · USJohns Hopkins University · USNeurobehavioral Systems · USUCLA Health · USUCLA Jonsson Comprehensive Cancer CenterUniversity of California, Los Angeles · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
A Phase III Randomized Trial Targeting Behavioral Symptoms in Younger Breast Cancer SurvivorsR01CA200977 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOWER, JULIENNE E, GANZ, PATRICIA A. · 2016 to 2020
$3.2M
NCATS NIH HHS UL1 TR001881NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA200977
6 · The paper itself

Abstract

purposeYounger women are at risk for depression and related symptoms following breast cancer. The Pathways to Wellness study, a randomized, multi-institution, three-arm trial, tested the efficacy of two behavioral interventions for younger breast cancer survivors with elevated depressive symptoms: mindful awareness practices (MAPs) and survivorship education (SE) (Clincaltrials.gov identifier: NCT03025139).

methodsWomen diagnosed with breast cancer at or before 50 years of age who had completed treatment and had elevated depressive symptoms were randomly assigned to 6 weeks of MAPs, SE, or wait-list control (WLC). Assessments were conducted preintervention and postintervention and at 3-month and 6-month postintervention follow-ups. Analyses compared each intervention to WLC using linear mixed models. The primary outcome was change in depressive symptoms from preintervention to postintervention on the Center for Epidemiologic Studies-Depression Scale; secondary outcomes included change in fatigue, insomnia, and vasomotor symptoms.

resultsTwo hundred forty-seven women (median age = 46 years) were randomly assigned to MAPs (n = 85), SE (n = 81), or WLC (n = 81). MAPs and SE led to significant decreases in depressive symptoms from preintervention to postintervention relative to WLC (mean change relative to WLC [95% CI]: MAPs, -4.7 [-7.5 to -1.9]; SE, -4.0 [-6.9 to -1.1]), which persisted at 6-month follow-up for MAPs (mean change relative to WLC [95% CI]: MAPs, -3.7 [-6.6 to -0.8]; SE, -2.8 [-5.9 to 0.2]). MAPs, but not SE, also had beneficial effects on fatigue, insomnia, and vasomotor symptoms that persisted at 6-month follow-up (

conclusionMindfulness meditation and SE reduced depressive symptoms in younger breast cancer survivors. These interventions can be widely disseminated over virtual platforms and have significant potential benefit for quality of life and overall survivorship in this vulnerable group.

Indexed as

AdultBreast NeoplasmsCancer SurvivorsCase-Control StudiesDepressionFatigueFemaleFollow-Up StudiesHumansMeditationMiddle AgedMindfulnessQuality of LifeRetrospective StudiesSleep Initiation and Maintenance DisordersSurvivorship

Identifiers

PMID34406839
PMCPMC8547916
OpenAlexW3195406826

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.