Evidence map›Paper›PMID 34406813›Full record

ArticleMicrobiology spectrum2021

Pre-Vaccine Positivity of SARS-CoV-2 Antibodies in Alberta, Canada during the First Two Waves of the COVID-19 Pandemic.

Carmen L Charlton, Leonard T Nguyen, Ashley Bailey, Jayne Fenton, Sabrina S Plitt, Carol Marohn, Cheryl Lau, Deena Hinshaw, Christie Lutsiak, Kimberley Simmonds and 5 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
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  7. Canada's approach to SARS-CoV-2 sero-surveillance: Lessons learned for routine surveillance and future pandemics.Canadian journal of public health = Revue canadienne de sante publique · 2024
    Article
  8. Article
  9. SARS-CoV-2 seroprevalence in Nova Scotia blood donors.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2024
    Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Carmen L CharltonPublic Health Laboratory, Alberta Precision Laboratories, Alberta, Canada.
Leonard T NguyenAlberta Precision Laboratories, Edmonton, Alberta, Canada.
Ashley BaileyPublic Health Laboratory, Alberta Precision Laboratories, Alberta, Canada.
Jayne FentonPublic Health Laboratory, Alberta Precision Laboratories, Alberta, Canada.
Sabrina S PlittCentre for Communicable Diseases and Infection Control, Public Health Agency of Canadagrid.415368.d (PHAC), Ottawa, Ontario, Canada.
Carol MarohnAlberta Precision Laboratories, Edmonton, Alberta, Canada.
Cheryl LauAlberta Precision Laboratories, Edmonton, Alberta, Canada.
Deena HinshawAlberta Ministry of Health, Edmonton, Alberta, Canada.
Christie LutsiakDepartment of Community Health Sciences, University of Calgarygrid.22072.35, Calgary, Alberta, Canada.
Kimberley SimmondsAlberta Ministry of Health, Edmonton, Alberta, Canada.
Jamil N KanjiPublic Health Laboratory, Alberta Precision Laboratories, Alberta, Canada.ORCID 0000-0002-1043-6807
Nathan ZelyasPublic Health Laboratory, Alberta Precision Laboratories, Alberta, Canada.
Nelson LeeDivision of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Albertagrid.17089.37, Edmonton, Alberta, Canada.
Michael MengelDepartment of Laboratory Medicine and Pathology, University of Albertagrid.17089.37, Edmonton, Alberta, Canada.
Graham TipplesPublic Health Laboratory, Alberta Precision Laboratories, Alberta, Canada.

Funding

Canadian Immunity Task ForceGovernment of Alberta (Alberta Government)
6 · The paper itself

Abstract

We systematically evaluated SARS-CoV-2 IgG positivity in a provincial cohort to understand the local epidemiology of COVID-19 and support evidence-based public health decisions. Residual blood samples were collected for serology testing over 5-day periods monthly from June 2020 to January 2021 from six clinical laboratories across the province of Alberta, Canada. A total of 93,993 individual patient samples were tested with a SARS-CoV-2 nucleocapsid antibody assay with positives confirmed using a spike antibody assay. Population-adjusted SARS-CoV-2 IgG seropositivity was 0.92% (95% confidence interval [CI]: 0.91 to 0.93%) shortly after the first COVID-19 wave in June 2020, increasing to 4.63% (95% CI: 4.61 to 4.65%) amid the second wave in January 2021. There was no significant difference in seropositivity between males and females (1.39% versus 1.27%;

Indexed as

PandemicsAdolescentAdultAgedAged, 80 and overAlbertaAntibodies, ViralAsymptomatic InfectionsChildChild, PreschoolCOVID-19COVID-19 VaccinesFemaleHumansImmunoglobulin GInfantAntibodies, ViralCOVID-19 VaccinesImmunoglobulin Gantibodyimmunologynucleocapsid proteinSARS-CoV-2serologyseroprevalencespike protein

Identifiers

PMID34406813
PMCPMC8552659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.