Evidence map›Paper›PMID 34406799›Full record

ArticleJournal of clinical microbiology2021

Azithromycin and Doxycycline Resistance Profiles of U.S. Mycoplasma genitalium Strains and Their Association with Treatment Outcomes.

Gwendolyn E Wood, Nicole L Jensen, Sabina Astete, Jørgen S Jensen, George E Kenny, Christine M Khosropour, Catherine W Gillespie, Lisa E Manhart, Patricia A Totten

Open access · hybridAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. German evidence- and consensus-based guideline on the management of penile urethritis.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025
    Guideline
  2. Antimicrobial resistance crisis in STIs: Gonorrhea andNew microbes and new infections · 2026
    Review
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  8. AutomatedMicrobiology spectrum · 2025
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  13. Clinical medicine & research · 2024
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  15. Efficacy of Minocycline for the Treatment ofOpen forum infectious diseases · 2023
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  16. Antimicrobial agents and chemotherapy · 2023
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  18. Omadacycline Is Highly ActiveMicrobiology spectrum · 2022
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  19. Molecular Typing Reveals DistinctMicroorganisms · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Gwendolyn E WoodDepartment of Medicine, University of Washingtongrid.34477.33, Seattle, Washington, USA.ORCID 0000-0001-5109-3794
Nicole L JensenDepartment of Medicine, University of Washingtongrid.34477.33, Seattle, Washington, USA.
Sabina AsteteDepartment of Medicine, University of Washingtongrid.34477.33, Seattle, Washington, USA.
Jørgen S JensenStatens Serum Institutgrid.6203.7, Copenhagen, Denmark.ORCID 0000-0002-7464-7435
George E KennyDepartment of Medicine, University of Washingtongrid.34477.33, Seattle, Washington, USA.
Christine M KhosropourDepartment of Epidemiology, University of Washingtongrid.34477.33, Seattle, Washington, USA.
Catherine W GillespieDepartment of Epidemiology, University of Washingtongrid.34477.33, Seattle, Washington, USA.
Lisa E Manhart *Department of Epidemiology, University of Washingtongrid.34477.33, Seattle, Washington, USA.
Patricia A Totten *Department of Medicine, University of Washingtongrid.34477.33, Seattle, Washington, USA.
University of Washington · USStatens Serum Institut · DK

Funding

VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
University of Washington STI-TM Cooperative Research CtrU19AI031448 · NIAID · UNIVERSITY OF WASHINGTON · PI HOLMES, KING K. · 1995 to 2010
$15.2M
NIAID NIH HHS T32 AI007140NIAID NIH HHS U19 AI031448NIH HHS U19AI31448
6 · The paper itself

Abstract

Mycoplasma genitalium is a sexually transmitted bacterium associated with nongonococcal urethritis (NGU) in men and cervicitis, endometritis, and pelvic inflammatory disease in women. Effective treatment is challenging due to the inherent, and increasingly acquired, antibiotic resistance in this pathogen. In our treatment trial conducted from 2007 to 2011 in Seattle, WA, we demonstrated poor efficacy of azithromycin (AZM) and doxycycline (DOX) against M. genitalium among men with NGU. In the present study, we cultured M. genitalium from 74 of 80 (92.5%) PCR-positive men at enrollment (V-1) and defined the MICs of AZM (

Indexed as

Mycoplasma genitaliumMycoplasma InfectionsUrethritisAnti-Bacterial AgentsAzithromycinDoxycyclineDrug Resistance, BacterialFemaleHumansMaleTreatment OutcomeAnti-Bacterial AgentsAzithromycinDoxycyclineantibiotic resistanceantibioticsantimicrobial agentsazithromycindoxycyclineMICsMycoplasma genitaliumnongonococcal urethritis

Identifiers

PMID34406799
PMCPMC8525566
OpenAlexW3196151797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.