Evidence map›Paper›PMID 34406789›Full record

ArticleMolecular biology of the cell2021

Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null

Amy S Fabritius, Brian A Bayless, Sam Li, Daniel Stoddard, Westley Heydeck, Christopher C Ebmeier, Lauren Anderson, Tess Gunnels, Chidambaram Nachiappan, Justen B Whittall and 4 more

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Microtubule inner proteins ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Amy S FabritiusDepartment of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616.
Brian A BaylessDepartment of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616.
Sam LiDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158.
Daniel StoddardDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Westley HeydeckDepartment of Molecular Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309.
Christopher C EbmeierDepartment of Molecular Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309.
Lauren AndersonDepartment of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616.
Tess GunnelsDepartment of Biology, Santa Clara University, Santa Clara, CA 95053.
Chidambaram NachiappanDepartment of Biology, Santa Clara University, Santa Clara, CA 95053.
Justen B WhittallDepartment of Biology, Santa Clara University, Santa Clara, CA 95053.
William OldDepartment of Molecular Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309.
David A AgardDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158.
Daniela NicastroDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Mark WineyDepartment of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616.
Santa Clara University · USUniversity of California, Davis · USUniversity of Colorado Boulder · USThe University of Texas Southwestern Medical Center · USUniversity of California, San Francisco · US

Funding

Structure and Function of Complexes that Regulate Ciliary MotilityR01GM083122 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Daniela Nicastro · 2007 to 2026
$6.2M
Structure & Mechanism: microtubule nucleation, centrosomes, phage cytoskeletonR35GM118099 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGARD, DAVID A. · 2016 to 2022
$3.6M
MIPS (Microtubule Inner Proteins) function in cilia and basal bodiesR01GM127571 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WINEY, MARK · 2018 to 2025
$2.5M
Acquisition of an electron microscope for high-resolution single particle cryo-EMS10OD021741 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2016 to 2016
$2.0M
Linux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456k
Identification and functional analysis of A-tubule MIPsR15GM143703 · NIGMS · SANTA CLARA UNIVERSITY · PI BAYLESS, BRIAN ANTHONY · 2021 to 2021
$408k
NIGMS NIH HHS R01 GM083122NIGMS NIH HHS R01 GM127571NIGMS NIH HHS R15 GM143703NIGMS NIH HHS R35 GM118099NIH HHS S10 OD020054NIH HHS S10 OD021741
6 · The paper itself

Abstract

The core structure of motile cilia and flagella, the axoneme, is built from a stable population of doublet microtubules. This unique stability is brought about, at least in part, by a network of microtubule inner proteins (MIPs) that are bound to the luminal side of the microtubule walls. Rib72A and Rib72B were identified as MIPs in the motile cilia of the protist

Indexed as

AxonemeCell MovementCiliaCryoelectron MicroscopyElectron Microscope TomographyFlagellaMicrotubule ProteinsMicrotubulesProtein StabilityProteomicsProtozoan ProteinsTetrahymenaMicrotubule ProteinsProtozoan Proteins

Identifiers

PMID34406789
PMCPMC8693976
OpenAlexW3194702254

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.