Evidence map›Paper›PMID 34406698›Full record

ArticleGlia2021

Astrocyte arborization enhances Ca

Samo Pirnat, Mićo Božić, Dorian Dolanc, Anemari Horvat, Petra Tavčar, Nina Vardjan, Alexei Verkhratsky, Robert Zorec, Matjaž Stenovec

Abstract read
In one paragraph

Article in Glia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Amyloid precursor protein induces reactive astrogliosis.bioRxiv : the preprint server for biology · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samo PirnatLaboratory of Cell Engineering, Celica BIOMEDICAL, Ljubljana, Slovenia.
Mićo BožićLaboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.
Dorian DolancLaboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.
Anemari HorvatLaboratory of Cell Engineering, Celica BIOMEDICAL, Ljubljana, Slovenia.
Petra TavčarLaboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.
Nina VardjanLaboratory of Cell Engineering, Celica BIOMEDICAL, Ljubljana, Slovenia.ORCID 0000-0001-8174-1668
Alexei VerkhratskyLaboratory of Cell Engineering, Celica BIOMEDICAL, Ljubljana, Slovenia.
Robert ZorecLaboratory of Cell Engineering, Celica BIOMEDICAL, Ljubljana, Slovenia.ORCID 0000-0002-7478-3875
Matjaž StenovecLaboratory of Cell Engineering, Celica BIOMEDICAL, Ljubljana, Slovenia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The plasticity of astrocytes is fundamental for their principal function, maintaining homeostasis of the central nervous system throughout life, and is associated with diverse exposomal challenges. Here, we used cultured astrocytes to investigate at subcellular level basic cell processes under controlled environmental conditions. We compared astroglial functional and signaling plasticity in standard serum-containing growth medium, a condition mimicking pathologic conditions, and in medium without serum, favoring the acquisition of arborized morphology. Using opto-/electrophysiologic techniques, we examined cell viability, expression of astroglial markers, vesicle dynamics, and cytosolic Ca

Indexed as

AstrocytesSignal TransductionCalcium SignalingCells, CulturedastrocyteCa2 +cAMPconfocal microscopyelectrophysiologyvesicles

Identifiers

PMID34406698
PMCPMC9290837

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.