ArticleAmerican journal of hematology2021
The International Hemoglobinopathy Research Network (INHERENT): An international initiative to study the role of genetic modifiers in hemoglobinopathies.
Registry-linked trialAbstract readLetter
In one paragraph
Article in American journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05799118 (Study of the Role of Genetic Modifiers in Hemoglobinopathies), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of the Role of Genetic Modifiers in Hemoglobinopathies
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetic Polymorphisms Associated with Fetal Hemoglobin (HbF) Levels and F-Cell Numbers: A Systematic Review of Genome-Wide Association Studies.International journal of molecular sciences · 2024Pooled it
- Systematic Review of Genetic Modifiers Associated with the Development and/or Progression of Nephropathy in Patients with Sickle Cell Disease.International journal of molecular sciences · 2024Pooled it
- Mapping diagnostic practices in hemoglobinopathies: a cross-country HELIOS COST Action study.Blood advances · 2026Article
- Mapping Current and Emerging Laboratory Techniques for Haemoglobinopathy Carrier Detection and Prevention: A Narrative Review from the HELIOS Action.International journal of molecular sciences · 2026Review
- FAIR data gaps and collaboration willingness among hemoglobinopathy research centers.Scientific data · 2026Article
- Special Issue "Genetic Modifiers of Hemoglobinopathies: Recent Advances and Future Directions".International journal of molecular sciences · 2026Article
- Review
- HELIOS Action: Advancing research, education, and equity in hemoglobinopathies across Europe and beyond.HemaSphere · 2025Article
- Ethical and regulatory requirements for conducting researcher-driven large-scale multinational genetic haematological studies: the INHERENT experience.Health research policy and systems · 2025Article
- Genetic Modifiers Associated with Vaso-Occlusive Crises and Acute Pain Phenomena in Sickle Cell Disease: A Scoping Review.International journal of molecular sciences · 2025Article
- A β-Thalassemia Cell Biobank: Updates, Further Validation in Genetic and Therapeutic Research and Opportunities During (and After) the COVID-19 Pandemic.Journal of clinical medicine · 2025Article
- Common Genetic Variants in Rare Disorders: Hematology and Beyond.Current issues in molecular biology · 2025Article
- Genetic Modifiers of Hemoglobin Expression from a Clinical Perspective in Hemoglobinopathy Patients with Beta Thalassemia and Sickle Cell Disease.International journal of molecular sciences · 2024Review
- Global Globin Network and adopting genomic variant database requirements for thalassemia.Database : the journal of biological databases and curation · 2024Article
- Genetic Modifiers of Stroke in Patients with Sickle Cell Disease-A Scoping Review.International journal of molecular sciences · 2024Article
- Genetics and Epigenetics in Acquired Hemophilia A: From Bench to Bedside.Current issues in molecular biology · 2024Review
- Pulmonary Hypertension in Sickle Cell Disease: Novel Findings of Gene Polymorphisms Related to Pathophysiology.International journal of molecular sciences · 2024Review
- Pharmacogenomics of Drugs Used in β-Thalassemia and Sickle-Cell Disease: From Basic Research to Clinical Applications.International journal of molecular sciences · 2024Review
- Impact of α-Globin Gene Expression and α-Globin Modifiers on the Phenotype of β-Thalassemia and Other Hemoglobinopathies: Implications for Patient Management.International journal of molecular sciences · 2024Review
- Special Issue "Personalized Medicine in Blood Disease of Children".Journal of personalized medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Petros KountourisThe Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.ORCID 0000-0003-2681-4355
Coralea StephanouThe Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Natasha ArcherPediatric Hematology/Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.
Fedele BonifaziFondazione per la Ricerca Farmacologica Gianni Benzi Onlus, Bari, Italy.
Viviana GiannuzziFondazione per la Ricerca Farmacologica Gianni Benzi Onlus, Bari, Italy.
Kevin H M KuoDivision of Hematology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Aurelio MaggioA.O. Villa Sofia-Cervello, Palermo, Italy.ORCID 0000-0002-9601-900X
Julie MakaniMuhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
María Del Mar Mañú-PereiraTranslational Research in Child and Adolescent Cancer. Vall d'Hebron Institut de recerca, Barcelona, Spain.
Kyriaki MichailidouThe Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Siana NkyaMuhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Obiageli E NnoduDepartment of Haematology and Blood Transfusion, University of Abuja, Abuja, Nigeria.
Sara TrompeterUniversity College London Hospitals NHS Trust, London, UK.
Léon TshiloloCentre Hospitalier Monkole and CEFA-Institut de Recherche Biomédicale, Kinshasa, Democratic Republic of Congo.ORCID 0000-0002-6318-0227
Ambroise WonkamUniversity of Cape Town, Cape Town, South Africa.
Bin Alwi ZilfalilUniversiti Sains Malaysia, Health Campus, Kelantan, Malaysia.
Baba P D InusaPaediatric Haematology, Evelina London Children's Hospital, Guy's & St. Thomas' Hospital NHS Foundation Trust, London, UK.ORCID 0000-0003-2643-765X
Marina KleanthousThe Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
on behalf of the International Hemoglobinopathy Research Network (INHERENT)
Funding
Sickle Africa Data Coordinating CenterU24HL135600 · NHLBI · UNIVERSITY OF CAPE TOWN · PI MULDER, NICOLA, WONKAM, AMBROISE · 2017 to 2025
$8.6MDevelopment of a Clinical Hemoglobin ModulatorR33HL147845 · NHLBI · PHOENICIA BIOSCIENCES, INC. · PI FALLER, DOUGLAS V, KUO, KEVIN · 2020 to 2022
$5.2MNHLBI NIH HHS R33 HL147845NHLBI NIH HHS U24 HL135600
Abstract
PubMed holds no abstract for this paper.
Indexed as
Anemia, Sickle CellDatabases, FactualGenetic Predisposition to DiseaseGenetic VariationHemoglobinopathiesHumans
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT05799118ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.