Evidence map›Paper›PMID 34406623›Full record

Trial reportAnnals of nuclear medicine2021

Determining the extent of tumor resection at surgical planning with

Toshihiko Wakabayashi, Yuichi Hirose, Keisuke Miyake, Yoshiki Arakawa, Naoki Kagawa, Tadashi Nariai, Yoshitaka Narita, Ryo Nishikawa, Naohiro Tsuyuguchi, Tadateru Fukami and 11 more

2 registry-linked trialsAbstract readMulticenter StudyClinical Trial, Phase III
PubMed Publisher
In one paragraph

Trial report in Annals of nuclear medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05554302 phase2recruitingnot on this mapstarted 2023, after this paper: background citation

Characterization of 18F-Fluciclovine PET Amino Acid Radiotracer in Resected Brain Metastasis

TypeinterventionalSponsorBaptist Health South FloridaRan2023 to 2030Enrolled20ConditionsBrain Metastases, Brain CancerArms18F-Fluciclovine
NCT06048094 phase1recruitingnot on this mapstarted 2024, after this paper: background citation

18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery (FACILITATE)

TypeinterventionalSponsorBaptist Health South FloridaRan2024 to 2033Enrolled46ConditionsBrain Metastases, Brain Metastases, Adult, Brain CancerArms18F fluciclovine
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Clinical Practice Guidelines forAnnals of nuclear medicine · 2025
    Guideline
  2. Annals of nuclear medicine · 2025
    Trial
  3. Review
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  9. Diagnostic Accuracy of PET withDiagnostics (Basel, Switzerland) · 2023
    Review
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  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 19 institutions in 1 country.

Toshihiko WakabayashiDepartment of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
Yuichi HiroseDepartment of Neurosurgery, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Keisuke MiyakeDepartment of Neurological Surgery, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Yoshiki ArakawaDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Naoki KagawaDepartment of Neurosurgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Tadashi NariaiDepartment of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Yoshitaka NaritaDepartment of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Ryo NishikawaDepartment of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan.
Naohiro TsuyuguchiDepartment of Neurosurgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
Tadateru FukamiDepartment of Neurosurgery, Shiga University of Medical Science, Seta-Tsukinowa-Cho, Otsu, Shiga, 520-2192, Japan.
Hikaru SasakiDepartment of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Takashi SasayamaDepartment of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Akihide KondoDepartment of Neurosurgery, Juntendo Tokyo Koto Geriatric Medical Center, 3-3-20 Shinsuna, Koto-ku, Tokyo, 136-0075, Japan.
Toshihiko IuchiDivision of Neurological Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan.
Hiroshi MatsudaIntegrative Brain Imaging Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi-cho, Kodaira, Tokyo, 187-8551, Japan.
Kazuo KubotaDepartment of Radiology, Southern Tohoku General Hospital, 7-115, Yatsuyamada, Koriyama, Fukushima, 963-8563, Japan.
Ryogo MinamimotoDepartment of Nuclear Medicine, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.
Takashi TerauchiDepartment of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
Yoichi NakazatoDepartment of Pathology, Hidaka Hospital, 886 Nakao-machi, Takasaki, Gunma, 370-0001, Japan.
Kan KubomuraClinical Development Department, Nihon Medi-Physics Co., Ltd, 3-4-10 Shinsuna, Koto-ku, Tokyo, 136-0075, Japan.
Masatoshi WadaClinical Development Department, Nihon Medi-Physics Co., Ltd, 3-4-10 Shinsuna, Koto-ku, Tokyo, 136-0075, Japan. masatoshi_wada@nmp.co.jp.ORCID http://orcid.org/0000-0002-2137-1746
Nihon Medi-Physics (Japan) · JPChiba Cancer Center · JPFujita Health University Hospital · JPHidaka Hospital · JPJapanese Foundation For Cancer Research · JPKagawa University · JPKeio University · JPKobe University · JPKoto Hospital · JPKyoto University · JPNagoya University · JPNational Center for Global Health and Medicine · JPNational Center of Neurology and Psychiatry · JPOsaka City University · JPSaitama Medical University · JPShiga University of Medical Science · JPSouthern Tohoku General Hospital · JPThe University of Osaka · JPTokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveGlioma is the most common type of central nervous system tumor reported worldwide. Current imaging technologies have limitations in the diagnosis and assessment of glioma. The present study aimed to confirm the diagnostic efficacy and safety of anti-1-amino-3-[

methodsCombined data from two multicenter, open-label phase III clinical trials were evaluated for this study. The two trials enrolled patients with suspected high- or low-grade glioma on the basis of clinical symptoms, clinical course, and magnetic resonance imaging findings, and who were scheduled for tumor resection surgery. Patients fasted for ≥ 4 h and received 2 mL of

resultsA total of 45 patients aged 23-89 years underwent

conclusion

trial registrationThese trials were registered in the Japan Pharmaceutical Information Center Clinical Trials Information (JapicCTI-152986, JapicCTI-152985).

Indexed as

Brain NeoplasmsCarboxylic AcidsCyclobutanesGliomaPositron Emission Tomography Computed TomographyAdultAgedFemaleHumansMaleMiddle AgedSafetyYoung AdultCarboxylic AcidsCyclobutanesfluciclovine F-1818F-fluciclovineGliomaPhase III trialPositron emission tomographySurgical planning

Identifiers

PMID34406623
OpenAlexW3194602940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.