Evidence map›Paper›PMID 34406584›Full record

SynthesisDigestive diseases and sciences2022

Yield of Surveillance Colonoscopy in Older Adults with a History of Polyps: A Systematic Review and Meta-Analysis.

Gregory J Williams, Sage T Hellerstedt, Paige N Scudder, Audrey H Calderwood

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gregory J Williams *The Dartmouth Institute of Health Policy and Clinical Practice, Lebanon, NH, USA.
Sage T Hellerstedt *The Dartmouth Institute of Health Policy and Clinical Practice, Lebanon, NH, USA.
Paige N ScudderDartmouth Biomedical Libraries, Dartmouth College, Hanover, NH, USA.
Audrey H CalderwoodThe Dartmouth Institute of Health Policy and Clinical Practice, Lebanon, NH, USA. audrey.h.calderwood@hitchcock.org.ORCID 0000-0001-7486-8310
Dartmouth College · USDartmouth Institute for Health Policy and Clinical Practice · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
SYNERGY: The Dartmouth Center for clinical and Translational ScienceUL1TR001086 · NCATS · DARTMOUTH COLLEGE · PI GREEN, ALAN I · 2013 to 2017
$18.3M
Reducing Inappropriate Use of Surveillance Colonoscopy in Older AdultsR21CA227776 · NCI · DARTMOUTH-HITCHCOCK CLINIC · PI CALDERWOOD, AUDREY HONG · 2019 to 2020
$375k
NCATS NIH HHS UL1 TR001086NCI NIH HHS P30 CA023108NCI NIH HHS R21CA22776-01A1NCI NIH HHS R21 CA227776
6 · The paper itself

Abstract

backgroundThe benefit of surveillance colonoscopy in older adults is not well described.

aimsTo quantify the detection of colorectal cancer (CRC) and advanced polyps during surveillance colonoscopy in older adults with a history of colon polyps.

methodsWe conducted a systematic review (MEDLINE, Cochrane Library, Web of Science, and Embase) for all published studies through May 2020 in adults age > 70 undergoing surveillance colonoscopy. The main outcome was CRC and advanced polyps detection. We performed meta-analysis to pool results by age (>70 vs. 50-70).

resultsThe search identified 6239 studies, of which 569 underwent full-text review and 64 data abstraction, of which 19 were included. The risk of detecting CRC (N = 11) was higher in those >70 compared to 50-70 (risk ratio 1.5 (95% CI 1.1-2.2); risk difference 0.8% (95% CI -0.2%-1.8%)). Similarly, the risk of detecting advanced polyps (N = 8) was higher in those >70 compared to 50-70 (risk ratio 1.3 (95% CI 1.2-1.3), risk difference 2.7% (95% CI 1.3%-4.0%)). Most studies did not stratify results by baseline polyp risk.

conclusionsThe detection of CRC and advanced polyps during surveillance colonoscopy in older individuals was higher than in younger controls; however, the absolute risk increase for both was small. These differences must be weighed against competing medical problems and limited life expectancy in older adults when making decisions about surveillance colonoscopy. More primary data on the risks of CRC and advanced polyps accounting for number of past colonoscopies, prior polyp risk, and duration of time since last polyp are needed.

Indexed as

Colonic PolypsColorectal NeoplasmsAgedColonoscopyHumansOdds RatioAdenomasAgeColorectal cancerElderlySurveillance

Identifiers

PMID34406584
PMCPMC10753972
OpenAlexW3195993598

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.