ArticleInternational journal of computer assisted radiology and surgery2021
Definition and extraction of 2D shape indices of intracranial aneurysm necks for rupture risk assessment.
Article in International journal of computer assisted radiology and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- Morphological Stability of Intracranial Aneurysms and the Contour Neurovascular System: A Longitudinal Analysis.Cardiovascular engineering and technology · 2026Article
- Assessment of intracranial aneurysm neck deformation after contour deployment.International journal of computer assisted radiology and surgery · 2024Article
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7 authors at 3 institutions in 1 country.
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Abstract
purposeIntracranial aneurysms are local dilations of brain vessels. Their rupture, as well as their treatment, is associated with high risk of morbidity and mortality. In this work, we propose shape indices for aneurysm ostia for the rupture risk assessment of intracranial aneurysms.
methodsWe analyzed 84 middle cerebral artery bifurcation aneurysms (27 ruptured and 57 unruptured) and their ostia, with respect to their size and shape. We extracted 3D models of the aneurysms and vascular trees. A semi-automatic approach was used to separate the aneurysm from its parent vessel and to reconstruct the ostium. We used known indices to quantitatively describe the aneurysms. For the ostium, we present new shape indices: the 2D Undulation Index (UI[Formula: see text]), the 2D Ellipticity Index (EI[Formula: see text]) and the 2D Noncircularity Index (NCI[Formula: see text]). Results were analyzed using the Student t test, the Mann-Whitney U test and a correlation analysis between indices of the aneurysms and their ostia.
resultsOf the indices, none was significantly associated with rupture status. Most aneurysms have an NCI[Formula: see text] below 0.2. Of the aneurysms that have an NCI[Formula: see text] above 0.5, only one is ruptured, which indicates that ruptured aneurysms often have a circular-shaped ostium. Furthermore, the ostia of ruptured aneurysms tend to have a smaller area, which is also correlated with the aneurysm's size. While also other variables were significantly correlated, strong linear correlations can only be seen between the area of the ostium with the aneurysm's volume and surface.
conclusionThe proposed shape indices open up new possibilities to quantitatively describe and compare ostia, which can be beneficial for rupture risk assessment and subsequent treatment decision. Additionally, this work shows that the ostium area and the size of the aneurysm are correlated. Further longitudinal studies are necessary to analyze whether stable and unstable aneurysms can be distinguished by their ostia.
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