Evidence map›Paper›PMID 34406554›Full record

SynthesisSleep & breathing = Schlaf & Atmung2022

Diagnostic accuracy of screening questionnaires for obstructive sleep apnoea in adults in different clinical cohorts: a systematic review and meta-analysis.

Lizelle Bernhardt, Emer M Brady, Suzanne C Freeman, Helena Polmann, Jéssica Conti Réus, Carlos Flores-Mir, Graziela De Luca Canto, Noelle Robertson, Iain B Squire

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Sleep & breathing = Schlaf & Atmung, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Pooled it
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  4. Trial
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  6. Review
  7. Chinese Guidelines for the Diagnosis and Surgical Treatment of Adult Obstructive Sleep Apnea (2024).World journal of otorhinolaryngology - head and neck surgery · 2026
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  8. Review
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  13. Assessing the effectiveness of the Friedman classification and its components in predicting obstructive sleep apnea: a Brazilian cross-sectional study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  14. Article
  15. Screening Obstructive Sleep Apnea in Chinese Adults: Optimizing STOP-Bang and NoSAS Cutoff Values.Medical science monitor : international medical journal of experimental and clinical research · 2025
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  19. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Lizelle BernhardtDepartment of Cardiovascular Sciences and NIHR Biomedical Research Centre, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK. lb382@le.ac.uk.ORCID 0000-0002-6010-3955
Emer M BradyDepartment of Cardiovascular Sciences and NIHR Biomedical Research Centre, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK.ORCID 0000-0002-4715-9145
Suzanne C FreemanDepartment of Health Sciences, University of Leicester, Leicester, UK.ORCID 0000-0001-8045-4405
Helena PolmannBrazilian Centre for Evidence-Based Research, Federal University of Santa Catarina, Florianopolis, Brazil.ORCID 0000-0002-6398-8787
Jéssica Conti RéusBrazilian Centre for Evidence-Based Research, Federal University of Santa Catarina, Florianopolis, Brazil.ORCID 0000-0001-6047-9381
Carlos Flores-MirDepartment of Dentistry, University of Alberta, Edmonton, Canada.ORCID 0000-0002-0887-9385
Graziela De Luca CantoBrazilian Centre for Evidence-Based Research, Federal University of Santa Catarina, Florianopolis, Brazil.ORCID 0000-0002-7986-8317
Noelle RobertsonDepartment of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK.ORCID 0000-0003-1178-9230
Iain B SquireDepartment of Cardiovascular Sciences and NIHR Biomedical Research Centre, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK.ORCID 0000-0002-6282-4318
University of Leicester · GBUniversidade Federal de Santa Catarina · BRUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe majority of individuals with clinically significant obstructive sleep apnoea (OSA) are undiagnosed and untreated. A simple screening tool may support risk stratification, identification, and appropriate management of at-risk patients. Therefore, this systematic review and meta-analysis evaluated and compared the accuracy and clinical utility of existing screening questionnaires for identifying OSA in different clinical cohorts.

methodsWe conducted a systematic review and meta-analysis of observational studies assessing the diagnostic value of OSA screening questionnaires. We identified prospective studies, validated against polysomnography, and published to December 2020 from online databases. To pool the results, we used random effects bivariate binomial meta-analysis.

resultsWe included 38 studies across three clinical cohorts in the meta-analysis. In the sleep clinic cohort, the Berlin questionnaire's pooled sensitivity for apnoea-hypopnoea index (AHI) ≥ 5, ≥ 15, and ≥ 30 was 85%, 84%, and 89%, and pooled specificity was 43%, 30%, and 33%, respectively. The STOP questionnaire's pooled sensitivity for AHI ≥ 5, ≥ 15, and ≥ 30 was 90%, 90%, and 95%, and pooled specificity was 31%, 29%, and 21%. The pooled sensitivity of the STOP-Bang questionnaire for AHI ≥ 5, ≥ 15, and ≥ 30 was 92%, 95%, and 96%, and pooled specificity was 35%, 27%, and 28%. In the surgical cohort (AHI ≥ 15), the Berlin and STOP-Bang questionnaires' pooled sensitivity were 76% and 90% and pooled specificity 47% and 27%.

conclusionAmong the identified questionnaires, the STOP-Bang questionnaire had the highest sensitivity to detect OSA but lacked specificity. Subgroup analysis considering other at-risk populations was not possible. Our observations are limited by the low certainty level in available data.

Indexed as

Sleep Apnea, ObstructiveAdultHumansMass ScreeningPolysomnographyProspective StudiesSurveys and QuestionnairesDiagnostic accuracyMeta-analysisObstructive sleep apnoeaScreening questionnairesSystematic review

Identifiers

PMID34406554
PMCPMC8370860
OpenAlexW3196170572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.