Evidence map›Paper›PMID 34406523›Full record

ArticleJournal of materials science. Materials in medicine2021

Improved cytocompatibility and antibacterial properties of zinc-substituted brushite bone cement based on β-tricalcium phosphate.

Inna V Fadeeva, Margarita A Goldberg, Ilya I Preobrazhensky, Georgy V Mamin, Galina A Davidova, Nadezhda V Agafonova, Marco Fosca, Fabrizio Russo, Sergey M Barinov, Simona Cavalu and 1 more

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In one paragraph

Article in Journal of materials science. Materials in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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  14. The Effect of Full-Scale Exchange of CaBiomimetics (Basel, Switzerland) · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. New Series of Red-Light Phosphor CaMolecules (Basel, Switzerland) · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Inna V FadeevaA.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Leninsky pr. 49, Moscow, Russian Federation, 119334.
Margarita A GoldbergA.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Leninsky pr. 49, Moscow, Russian Federation, 119334.
Ilya I PreobrazhenskyDepartment of Materials Science, M.V. Lomonosov Moscow State University, Leninskie Gory 1, Moscow, Russian Federation, 119991.
Georgy V MaminKazan Federal University, Kremlevskaya 18, Kazan, Russian Federation, 420008.
Galina A DavidovaInstitute of Theoretical and Experimental Biophysics of Russian Academy of Sciences, Institutskaya 3, Pushchino, Moscow, Russian Federation, 142290.
Nadezhda V AgafonovaG.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", pr. Nauki, 5, Pushchino, Moscow Region, Russian Federation, 142290.
Marco FoscaIstituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere 100, 00133, Rome, Italy.
Fabrizio RussoDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo 200, 00128, Rome, Italy.
Sergey M BarinovA.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Leninsky pr. 49, Moscow, Russian Federation, 119334.
Simona CavaluFaculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410073, Oradea, Romania.
Julietta V RauIstituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere 100, 00133, Rome, Italy. giulietta.rau@ism.cnr.it.ORCID http://orcid.org/0000-0002-7953-1853

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCP were prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, and compressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture of brushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblast NCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn

Indexed as

Bone CementsBone SubstitutesAnimalsAnti-Bacterial AgentsCalcium PhosphatesCell SurvivalCompressive StrengthDurapatiteElectron Spin Resonance SpectroscopyEnterococcus faeciumEscherichia coliHydrogen-Ion ConcentrationIonsMaterials TestingMiceMicrobial Sensitivity TestsAnti-Bacterial Agentsbeta-tricalcium phosphateBone CementsBone Substitutescalcium phosphate, dibasic, dihydrateCalcium PhosphatesDurapatiteIonsPowderstricalcium phosphateZinc

Identifiers

PMID34406523
PMCPMC8373736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.