Evidence map›Paper›PMID 34406503›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2022

Is pseudoexfoliation syndrome associated with vitreoretinal interface abnormalities?

Seda Karaca Adıyeke, Neslisah Kutlu, Kıvanç Özen, Mehmet Ali Doran, Kemal Demirbaş, Gamze Ture, Ekrem Talay

Abstract read
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Epiretinal membrane prevalence in asymmetrical pseudoexfoliation glaucoma and its impact on glaucoma monitoring parameters including peripapillary vessel density.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  2. Observational
  3. Vitreoretinal interface features in epiretinal membrane associated with pseudoexfoliation syndrome.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Seda Karaca AdıyekeTepecik Research and Training Hospital Ophthalmology Department, Izmir, Turkey. skaracaadiyeke@hotmail.com.ORCID http://orcid.org/0000-0003-1651-2943
Neslisah KutluTepecik Research and Training Hospital Ophthalmology Department, Izmir, Turkey.
Kıvanç ÖzenTepecik Research and Training Hospital Ophthalmology Department, Izmir, Turkey.
Mehmet Ali DoranTepecik Research and Training Hospital Ophthalmology Department, Izmir, Turkey.
Kemal DemirbaşTepecik Research and Training Hospital Ophthalmology Department, Izmir, Turkey.
Gamze TureTepecik Research and Training Hospital Ophthalmology Department, Izmir, Turkey.
Ekrem TalayTepecik Research and Training Hospital Ophthalmology Department, Izmir, Turkey.
Education Training And Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate vitreoretinal interface abnormalities in patients with pseudoexfoliation (PEX) syndrome.

methodsThis case-control study was performed in 136 patients diagnosed with unilateral PEX (PEX group) and 139 age- and sex-matched healthy volunteers (Control group). Both the affected and contralateral eyes were evaluated in the PEX group and the right eye was evaluated in the Control group. Vitreoretinal interface abnormalities and posterior vitreous detachment (PVD) were evaluated on optical coherence tomography (OCT) examination.

resultsThe incidences of incomplete and complete PVD were significantly higher in the affected than contralateral eye in the PEX group and in the right eye in the Control group (P = 0.009, P = 0.012 and P = 0.004, P = 0.017, respectively). The rates of 'no PVD' were significantly higher in the contralateral eye in the PEX group and the Control group compared to the affected eye in the PEX group (P = 0.003 and P = 0.001, respectively). The odds ratio for incomplete PVD was 3.1 in PEX eyes compared to the contralateral eye in the PEX group and 3.9 compared to the Control group. The rate of epiretinal membranes (ERMs) in the affected eye was significantly different from the contralateral eye in the PEX and Control groups (P < 0.001 and P < 0.001, respectively). The odds ratio for ERM in PEX eyes was 3.51 compared to the contralateral eye in the PEX group and 4.23 compared to the Control group. In the presence of incomplete PVD, the odds ratio for ERM development was 3.81 in PEX eyes.

conclusionsWe detected high rates of ERMs and incomplete PVD in patients with PEX. It is important to evaluate and follow up PEX cases in terms of vitreoretinal interface abnormalities.

Indexed as

Epiretinal MembraneExfoliation SyndromeVitreous DetachmentCase-Control StudiesHumansTomography, Optical CoherenceEpiretinal membranePosterior hyaloid detachmentPseudoexfoliation syndromeVitreoretinal interface

Identifiers

PMID34406503
OpenAlexW3194231217

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.