Evidence map›Paper›PMID 34406491›Full record

ArticleLangenbeck's archives of surgery2022

Association between number of parathyroid glands identified during total thyroidectomy and functional parathyroid preservation.

Fiona Riordan, Matthew S Murphy, Linda Feeley, Patrick Sheahan

Open access · hybridAbstract read
In one paragraph

Article in Langenbeck's archives of surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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  6. Preoperative vitamin D administration does not affect rates of post-thyroidectomy hypocalcaemia.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Fiona RiordanDepartment of Otolaryngology, Head and Neck Surgery, South Infirmary Victoria University Hospital, Cork, T12, Ireland.
Matthew S MurphyDepartment of Endocrinology, South Infirmary Victoria University Hospital, Cork, Ireland.
Linda FeeleyDepartment of Pathology, Cork University Hospital, Cork, Ireland.
Patrick SheahanDepartment of Otolaryngology, Head and Neck Surgery, South Infirmary Victoria University Hospital, Cork, T12, Ireland. sheahan.patrick@sivuh.ie.ORCID http://orcid.org/0000-0002-9153-8951
South Infirmary Victoria University Hospital · IEUniversity College Cork · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSystematic identification of all 4 parathyroid glands has been recommended during total thyroidectomy (TT); however, it is unclear whether this strategy necessarily translates into optimized functional parathyroid preservation. We wished to investigate the association between number of parathyroids identified intraoperatively during TT, and incidence of incidental parathyroidectomy, and postoperative hypoparathyroidism.

methodsRetrospective review of prospectively maintained database of 511 consecutive patients undergoing TT at an academic teaching hospital. The association between number of parathyroid glands identified intraoperatively and incidence of biochemical hypocalcaemia (defined as any calcium < 2 mmol/L n first 48 h after surgery), symptomatic hypocalcaemia; permanent hypoparathyroidism (defined as any hypocalcaemia or need for calcium or vitamin D > 6 months after surgery), and incidental parathyroidectomy, was investigated. The association between number of parathyroid glands visualized and postoperative parathyroid hormone (PTH) levels was investigated in a subset of 454 patients.

resultsPatients in whom a greater number of parathyroids had been identified had a significantly higher incidence of biochemical and symptomatic hypocalcaemia, and significantly lower postoperative PTH levels, than patients with fewer glands identified. There were no significant differences in incidence of permanent hypoparathyroidism or incidental parathyroidectomy. On multivariate analysis, malignancy, Graves disease, and identification of 3-4 parathyroids were independent predictors of biochemical hypocalcaemia. For symptomatic hypocalcaemia, identification of 2-4 parathyroids, and identification of 3-4 parathyroids, were significant.

conclusionsSystematic identification of as many parathyroid glands as possible during TT is not necessary for functional parathyroid preservation.

Indexed as

HypocalcemiaHypoparathyroidismCalciumHumansParathyroidectomyParathyroid GlandsParathyroid HormonePostoperative ComplicationsThyroidectomyCalciumParathyroid HormoneHypocalcemiaHypoparathyroidismParathyroidParathyroid identificationThyroidectomy

Identifiers

PMID34406491
PMCPMC8847165
OpenAlexW3193470506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.