ArticleBritish journal of neurosurgery2024
Resection of the piriform cortex for temporal lobe epilepsy: a Novel approach on imaging segmentation and surgical application.
Article in British journal of neurosurgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 9 citations in OpenAlex.
- Fully automated three-dimensional deep learning-based magnetic resonance imaging segmentation of brain cavities in epilepsy surgery.Epilepsia · 2026Article
- The Little-Known Ribbon-Shaped Piriform Cortex: A Key Node in Temporal Lobe Epilepsy-Anatomical Insights and Its Potential for Surgical Treatment.Diagnostics (Basel, Switzerland) · 2024Review
- Interictal blood-brain barrier dysfunction in piriform cortex of people with epilepsy.Annals of clinical and translational neurology · 2024Article
- Fully automatic segmentation of brain lacunas resulting from resective surgery using a 3D deep learning model.medRxiv : the preprint server for health sciences · 2024Article
- Extent of piriform cortex resection in children with temporal lobe epilepsy.Annals of clinical and translational neurology · 2023Article
- Automatic and manual segmentation of the piriform cortex: Method development and validation in patients with temporal lobe epilepsy and Alzheimer's disease.Human brain mapping · 2023Article
- The role of the piriform cortex in temporal lobe epilepsy: A current literature review.Frontiers in neurology · 2022Review
- Quelling the Area Tempesta: Removal of the Piriform Cortex Improves the Outcomes of Surgery for Temporal Lobe Epilepsy.Epilepsy currentsArticle
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14 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe piriform cortex (PC) occupies both banks of the endorhinal sulcus and has an important role in the pathophysiology of temporal lobe epilepsy (TLE). A recent study showed that resection of more than 50% of PC increased the odds of becoming seizure free by a factor of 16.
objectiveWe report the feasibility of manual segmentation of PC and application of the Geodesic Information Flows (GIF) algorithm to automated segmentation, to guide resection.
methodsManual segmentation of PC was performed by two blinded independent examiners in 60 patients with TLE (55% Left TLE, 52% female) with a median age of 35 years (IQR, 29-47 years) and 20 controls (60% Women) with a median age of 39.5 years (IQR, 31-49). The GIF algorithm was used to create an automated pipeline for parcellating PC which was used to guide excision as part of temporal lobe resection for TLE.
resultsRight PC was larger in patients and controls. Parcellation of PC was used to guide anterior temporal lobe resection, with subsequent seizure freedom and no visual field or language deficit.
conclusionReliable segmentation of PC is feasible and can be applied prospectively to guide neurosurgical resection that increases the chances of a good outcome from temporal lobe resection for TLE.
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