Evidence map›Paper›PMID 34406038›Full record

ArticleThe CRISPR journal2021

The View from the Benches: Scientists' Perspectives on the Uses and Governance of Human Gene-Editing Research.

Margaret Waltz, Eric T Juengst, Teresa Edwards, Gail E Henderson, Kristine J Kuczynski, John M Conley, Paige Della-Penna, R Jean Cadigan

Open access · greenAbstract read
In one paragraph

Article in The CRISPR journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The roadmap of bioeconomy in China.Engineering biology · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Margaret WaltzDepartment of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Chapel Hill, North Carolina, USA.
Eric T JuengstDepartment of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Chapel Hill, North Carolina, USA.
Teresa EdwardsH.W. Odum Institute for Research in Social Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Chapel Hill, North Carolina, USA.
Gail E HendersonDepartment of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Chapel Hill, North Carolina, USA.
Kristine J KuczynskiDepartment of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Chapel Hill, North Carolina, USA.
John M ConleyUniversity of North Carolina School of Law, Chapel Hill, North Carolina, USA; and Chapel Hill, North Carolina, USA.
Paige Della-PennaUniversity of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
R Jean CadiganDepartment of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · US

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
Incidental Enhancement: Addressing a Neglected Policy Issue in Human Genome EditingR01HG010661 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CADIGAN, ROSEMARY JEAN · 2020 to 2023
$3.1M
6 · The paper itself

Abstract

The advent of human gene editing has stimulated international interest in how best to govern this research. However, research on stakeholder views has neglected scientists themselves. We surveyed 212 scientists who use gene editing in their work. Questions captured views on oversight and use of somatic and germline human gene editing for treatment, prevention, and enhancement. More respondents were supportive of somatic than germline editing, and more supported gene editing for treatment compared to prevention. Few supported its use for enhancement. When presented with specific conditions, levels of support for somatic editing differed by type of condition. Almost all respondents said scientists and national government representatives should be involved in oversight, but only 28% said scientists are best positioned to oversee gene-editing research. These results can inform the development of sound approaches to research governance, demonstrating the importance of identifying specific gene-editing uses when considering oversight.

Indexed as

Attitude of Health PersonnelGene EditingResearchEducational StatusFemaleGerm CellsHealth PersonnelHumansMaleSurveys and Questionnaires

Identifiers

PMID34406038
PMCPMC8392077
OpenAlexW3194195809

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.