ReviewJournal of child psychology and psychiatry, and allied disciplines2021
Ethical dimensions of translational developmental neuroscience research in autism.
Review in Journal of child psychology and psychiatry, and allied disciplines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Complementary and Alternative Medicine for Autism - A Systematic Review.Journal of autism and developmental disorders · 2025Pooled it
- A Survey-Based Study Investigating Opinions on Genetic Research Among Swedish Autistic Individuals and Parents of Autistic Children.Autism : the international journal of research and practice · 2026Article
- Getting the timing right. Autistic adolescents reflect on the value of an early diagnosis.Frontiers in psychiatry · 2026Article
- Do all adolescents benefit equally from school-based mental health interventions? A subgroup analysis by depression severity at 12 and 18 months follow-up.Frontiers in psychiatry · 2026Article
- Integrating Gut-Brain Axis: Exploring the Neurogastrointestinal Interactions and Therapeutic Potentials in Autism Spectrum Disorder.Endocrine, metabolic & immune disorders drug targets · 2026Review
- Quo Vadis translational neuroscience?Translational neuroscience · 2026Review
- Generalisation of Social Communication Skills by Autistic Children During Play-Based Assessments Across Home, School and an Unfamiliar Research Setting.Journal of autism and developmental disorders · 2025Article
- An integrative approach between neurodiversity perspectives and quality of life models for autistic people across the spectrum of support needs.Frontiers in psychiatry · 2025Review
- The Earlier, the Better? An In-Depth Interview Study on the Ethics of Early Detection with Parents of Children at an Elevated Likelihood for Autism.Journal of autism and developmental disorders · 2024Article
- Moving from Disorder to Difference: A Systematic Review of Recent Language Use in Autism Research.Autism in adulthood · 2024Article
- Advances in physiological and clinical relevance of hiPSC-derived brain models for precision medicine pipelines.Frontiers in cellular neuroscience · 2024Review
- Three year outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder.JCPP advances · 2023Article
- A Developmental Social Neuroscience Perspective on Infant Autism Interventions.Annual review of developmental psychology · 2023Article
- Prediction of autism in infants: progress and challenges.The Lancet. Neurology · 2023Review
- Autistic Perspectives on the Future of Clinical Autism Research.Autism in adulthood · 2022Article
- Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays.Frontiers in neuroscience · 2022Article
- Perspectives on heterogeneity-informed cognitive training for attention-deficit/hyperactivity disorder.Frontiers in psychiatry · 2022Article
- Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda.Journal of neurodevelopmental disorders · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundSince the 1990s, increasing research has been devoted to the identification of biomarkers for autism to help attain more objective diagnosis; enable early prediction of prognosis; and guide individualized intervention options. Early studies focused on the identification of genetic variants associated with autism, but more recently, research has expanded to investigate neurodevelopmental markers. While ethicists have extensively discussed issues around advances in autism genomics, much less ethical scrutiny has focused on research on early neurodevelopment and on the interventions being developed as a result.
objectivesWe summarize the current state of the science on the identification of early markers for autism and its potential clinical applications, before providing an overview of the ethical issues arising from increasing understanding of children's neurodevelopment in very early life.
resultsAdvances in the understanding of brain and behavioral trajectories preceding later autism diagnosis raise ethical concerns around three themes: (a) New models for understanding autism; (b) Risks and benefits of early identification and intervention; and (c) Communication of early concerns to families. These ethical issues should be further investigated in research conducted in partnership with autistic people and their families.
conclusionsThis paper highlights the need for ethical scrutiny of early neurodevelopmental research in autism. Scrutiny requires expertise and methods from the basic sciences and bioethics, as well as constructive collaborations among autistic people, their parents, and autism researchers to anticipate early interventions that serve the community's interests and accommodate the varied experiences and preferences of people on the spectrum and their families.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.