Evidence map›Paper›PMID 34405687›Full record

ArticleCirculation research2021

Filamin C Cardiomyopathy Variants Cause Protein and Lysosome Accumulation.

Radhika Agarwal, Joao A Paulo, Christopher N Toepfer, Jourdan K Ewoldt, Subramanian Sundaram, Anant Chopra, Qi Zhang, Joshua Gorham, Steven R DePalma, Christopher S Chen and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  13. Dilated Cardiomyopathy: A Genetic Journey from Past to Future.International journal of molecular sciences · 2024
    Review
  14. Article
  15. Article
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  17. Loss of Sec-1 Family Domain-Containing 1 (Journal of cardiovascular development and disease · 2023
    Article
  18. The Genetic Evaluation of Dilated Cardiomyopathy.Structural heart : the journal of the Heart Team · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Radhika AgarwalDepartment of Genetics (R.A., C.N.T., Q.Z., J.G., S.R.D., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.
Joao A PauloDepartment of Cell Biology(J.A.P., S.P.G.), Harvard Medical School, Boston, MA.ORCID 0000-0002-4291-413X
Christopher N ToepferDepartment of Genetics (R.A., C.N.T., Q.Z., J.G., S.R.D., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.ORCID 0000-0003-4671-2030
Jourdan K EwoldtDepartment of Biomedical Engineering, Boston University, MA (J.K.E., S.S., A.C., C.S.C.).
Subramanian SundaramDepartment of Biomedical Engineering, Boston University, MA (J.K.E., S.S., A.C., C.S.C.).ORCID 0000-0002-8456-916X
Anant ChopraDepartment of Biomedical Engineering, Boston University, MA (J.K.E., S.S., A.C., C.S.C.).
Qi ZhangDepartment of Genetics (R.A., C.N.T., Q.Z., J.G., S.R.D., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.
Joshua GorhamDepartment of Genetics (R.A., C.N.T., Q.Z., J.G., S.R.D., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.ORCID 0000-0001-5969-4690
Steven R DePalmaDepartment of Genetics (R.A., C.N.T., Q.Z., J.G., S.R.D., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.ORCID 0000-0002-0381-5016
Christopher S ChenDepartment of Biomedical Engineering, Boston University, MA (J.K.E., S.S., A.C., C.S.C.).
Steven P Gygi *Department of Cell Biology(J.A.P., S.P.G.), Harvard Medical School, Boston, MA.
Christine E Seidman *Department of Genetics (R.A., C.N.T., Q.Z., J.G., S.R.D., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.ORCID 0000-0001-6380-1209
J G Seidman *Department of Genetics (R.A., C.N.T., Q.Z., J.G., S.R.D., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.ORCID 0000-0002-9082-3566
Harvard University · USBoston University · USBrigham and Women's Hospital · USCentre for Human Genetics · GB

Funding

Defining Pathways from Gene Mutation to Heart FailureR01HL080494 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CHEN, CHRISTOPHER S, SEIDMAN, CHRISTINE E · 2005 to 2024
$9.4M
Molecular Signaling in Hypertrophic CardiomyopathyR01HL084553 · NHLBI · HARVARD MEDICAL SCHOOL · PI SEIDMAN, JONATHAN G · 2007 to 2022
$5.9M
Advancing Multiplexed Isobaric Tag-based Strategies for Proteome ProfilingR01GM132129 · NIGMS · HARVARD MEDICAL SCHOOL · PI PAULO, JOAO A · 2019 to 2023
$1.7M
Characterizing the mechanism of loss-of-function mutations in ALPK3 in the pathogenesis of cardiomyopathyF30HL147389 · NHLBI · HARVARD MEDICAL SCHOOL · PI AGARWAL, RADHIKA · 2019 to 2021
$125k
British Heart Foundation RE/18/3/34214Howard Hughes Medical InstituteNHLBI NIH HHS F30 HL147389NHLBI NIH HHS R01 HL080494NHLBI NIH HHS R01 HL084553NIGMS NIH HHS R01 GM132129Sir Henry Wellcome 206466/Z/17/ZWellcome Trust 206466/Z/17/Z
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

CardiomyopathiesCells, CulturedFilaminsHumansInduced Pluripotent Stem CellsLysosomesMyocardial ContractionMyocytes, CardiacSarcomeresFilaminsFLNC protein, humancardiomyopathiesfilamininduced pluripotent stem celllysosomesarcomere

Identifiers

PMID34405687
PMCPMC9053646
OpenAlexW3195749763

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.