Evidence map›Paper›PMID 34405552›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology2022

Recent advances and applications of microspheres and nanoparticles in transarterial chemoembolization for hepatocellular carcinoma.

Guorong Jia, Juno Van Valkenburgh, Austin Z Chen, Quan Chen, Jindian Li, Changjing Zuo, Kai Chen

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Observational
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Embolic efficacy and safety profile of UniPearlsJournal of materials science. Materials in medicine · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Application of Nanotechnology in TACE Treatment of Liver Cancer.International journal of nanomedicine · 2025
    Review
  15. Unleashing the potential: transarterial chemoembolization combined with intra-arterial infusion of bevacizumab for unresectable hepatocellular carcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  16. Review
  17. Article
  18. Review
  19. Material characterization of GPXFrontiers in bioengineering and biotechnology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guorong JiaDepartment of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-1293-9387
Juno Van ValkenburghDepartment of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Austin Z ChenDepartment of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Quan ChenDepartment of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jindian LiDepartment of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Changjing ZuoDepartment of Nuclear Medicine, Changhai Hospital of Shanghai, Shanghai, China.ORCID 0000-0002-2051-766X
Kai ChenDepartment of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-8647-1182

Funding

USC RESEARCH CENTER FOR LIVER DISEASES: PILOT PROGRAMSP30DK048522 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OOKHTENS, MURAD · 1995 to 2020
$21.8M
NIDDK NIH HHS P30 DK048522
6 · The paper itself

Abstract

Transarterial chemoembolization (TACE) is a recommended treatment for patients suffering from intermediate and advanced hepatocellular carcinoma (HCC). As compared to the conventional TACE, drug-eluting bead TACE demonstrates several advantages in terms of survival, treatment response, and adverse effects. The selection of embolic agents is critical to the success of TACE. Many studies have been performed on the modification of the structure, size, homogeneity, biocompatibility, and biodegradability of embolic agents. Continuing efforts are focused on efficient loading of versatile chemotherapeutics, controlled sizes for sufficient occlusion, real-time detection intra- and post-procedure, and multimodality imaging-guided precise treatment. Here, we summarize recent advances and applications of microspheres and nanoparticles in TACE for HCC. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

Indexed as

Carcinoma, HepatocellularChemoembolization, TherapeuticLiver NeoplasmsNanoparticlesHumansMicrospheresTreatment Outcomehepatocellular carcinomaimagingmicrospheresnanoparticlestherapytransarterial chemoembolization

Identifiers

PMID34405552
PMCPMC8850537

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.