Evidence map›Paper›PMID 34405515›Full record

ArticleChembiochem : a European journal of chemical biology2021

Kinetic Studies of Acetyl Group Migration between the Saccharide Units in an Oligomannoside Trisaccharide Model Compound and a Native Galactoglucomannan Polysaccharide.

Robert Lassfolk, Sara Bertuzzi, Ana Ardá, Johan Wärnå, Jesús Jiménez-Barbero, Reko Leino

Open access · hybridAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Robert LassfolkLaboratory of Molecular Science and Engineering, Åbo Akademi University, 20500, Turku, Finland.
Sara BertuzziChemical Glycobiology Laboratory, CIC bioGUNE, Bizkaia Technology Park, Building 800, 48160, Derio, Spain.
Ana ArdáChemical Glycobiology Laboratory, CIC bioGUNE, Bizkaia Technology Park, Building 800, 48160, Derio, Spain.
Johan WärnåLaboratory of Industrial Chemistry and Reaction Engineering, Åbo Akademi University, 20500, Turku, Finland.
Jesús Jiménez-BarberoChemical Glycobiology Laboratory, CIC bioGUNE, Bizkaia Technology Park, Building 800, 48160, Derio, Spain.
Reko LeinoLaboratory of Molecular Science and Engineering, Åbo Akademi University, 20500, Turku, Finland.
Åbo Akademi University · FICIC bioGUNE · ES

Funding

Agencia Estatal de Investigación (Spain) RTI2018-094751-B-C21European Research Council 788143-RECGLYCA NMRMagnus Ehrnrooth foundationWaldemar von Frenckells foundation
6 · The paper itself

Abstract

Acyl group migration is a fundamental phenomenon in carbohydrate chemistry, recently shown to take place also between two non-adjacent hydroxyl groups, across the glycosidic bond, in a β-(1→4)-linked mannan trisaccharide model compound. With the central mannoside unit containing acetyl groups at the O2 and O3 positions, the O2-acetyl was in the earlier study shown to migrate to O6 of the reducing end. Potential implications of the general acyl migration process on cell signaling events and plant growth in nature are intriguing open questions. In the present work, migration kinetics in this original trisaccharide model system were studied in more detail together with potential interactions of the model compound and the migration products with DC-SIGN lectin. Furthermore, we demonstrate here for the first time that similar migration may also take place in native polysaccharides, here represented by galactoglucomannan from Norway spruce.

Indexed as

Carbohydrate ConformationGlycosidesKineticsMannansOligosaccharidesgalactoglucomannanGlycosidesMannansoligomannosideOligosaccharidesacyl migrationcarbohydratesC-type lectinDC-SIGNgalactoglucomannan

Identifiers

PMID34405515
PMCPMC8597014
OpenAlexW3194118027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.