Evidence map›Paper›PMID 34405373›Full record

ArticleProbiotics and antimicrobial proteins2023

Effect of Probiotics Lactobacillus acidophilus and Lacticaseibacillus rhamnosus on Antibacterial Response Gene Transcription of Human Peripheral Monocytes.

Glauber Campos Vale, Brenda Izabela Santana Mota, Ellen Sayuri Ando-Suguimoto, Marcia Pinto Alves Mayer

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. A Probiotic Mixture ofInternational journal of molecular sciences · 2025
    Article
  2. Genomic and functional insights intoFrontiers in microbiology · 2025
    Article
  3. Article
  4. Microorganisms · 2024
    Article
  5. Article
  6. Probiotics in Postoperative Pain Management.Journal of personalized medicine · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Frontiers in dental medicine · 2023
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Glauber Campos ValeRestorative Dentistry Department, Federal University of Piauí, Teresina, Brazil. glauber@ufpi.edu.br.ORCID 0000-0002-6055-9493
Brenda Izabela Santana MotaRestorative Dentistry Department, Federal University of Piauí, Teresina, Brazil.
Ellen Sayuri Ando-SuguimotoDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Marcia Pinto Alves MayerDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Universidade de São Paulo · BRUniversidade Federal do Piauí · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/18273-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/10829-3
6 · The paper itself

Abstract

Periodontitis and related systemic inflammatory diseases are characterized by imbalanced ratio between pro- and anti-inflammatory factors. Probiotics may control inflammation by altering the inflammatory phenotype of defense cells. We aimed to evaluate the gene transcription of the antibacterial response of monocytes to exposure to probiotic lactobacilli. CD14 + monocytes were obtained by positive selection from peripheral blood mononuclear cells from healthy donors (5 × 10

Indexed as

Lacticaseibacillus rhamnosusProbioticsCytokinesHumansLacticaseibacillusLactobacillus acidophilusLeukocytes, MononuclearMonocytesTranscription, GeneticTumor Necrosis Factor-alphaCytokinesTumor Necrosis Factor-alphaGene expressionImmunomodulationPeripheral monocytesProbiotics

Identifiers

PMID34405373
OpenAlexW3194944821

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.