Evidence map›Paper›PMID 34405304›Full record

ArticleApoptosis : an international journal on programmed cell death2021

Long-circulating XTEN864-annexin A5 fusion protein for phosphatidylserine-related therapeutic applications.

Akvile Haeckel, Lena Ascher, Nicola Beindorff, Sonal Prasad, Karolina Garczyńska, Jing Guo, Eyk Schellenberger

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Akvile HaeckelDepartment of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Lena AscherBundesanstalt für Materialforschung und -prüfung (BAM), Richard-Willstätter-Straße 11, 12489, Berlin, Germany.
Nicola BeindorffBerlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Sonal PrasadBerlin Experimental Radionuclide Imaging Center (BERIC), Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Karolina GarczyńskaDepartment of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Jing GuoDepartment of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Eyk SchellenbergerDepartment of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany. eyk.schellenberger@charite.de.ORCID 0000-0003-4096-6865
Charité - Universitätsmedizin Berlin · DEFederal Institute For Materials Research and Testing · DE

Funding

Deutsche Forschungsgemeinschaft SCHE 1416/11-1Deutsche Forschungsgemeinschaft SFB-1340 / B08
6 · The paper itself

Abstract

Annexin A5 (anxA5) is a marker for apoptosis, but has also therapeutic potential in cardiovascular diseases, cancer, and, due to apoptotic mimicry, against dangerous viruses, which is limited by the short blood circulation. An 864-amino-acid XTEN polypeptide was fused to anxA5. XTEN864-anxA5 was expressed in Escherichia coli and purified using XTEN as tag. XTEN864-anxA5 was coupled with DTPA and indium-111. After intravenous or subcutaneous injection of

Indexed as

Escherichia coliPhosphatidylserinesAnimalsAnnexin A5ApoptosisMiceTissue DistributionAnnexin A5PhosphatidylserinesApoptotic mimicryAtherosclerosisCancerInflammationInflammatory cytokine stormProgrammed cell death

Identifiers

PMID34405304
PMCPMC8370750
OpenAlexW3193583034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.