Evidence map›Paper›PMID 34405124›Full record

ArticleComputational toxicology (Amsterdam, Netherlands)2021

COSMOS next generation - A public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals.

C Yang, M T D Cronin, K B Arvidson, B Bienfait, S J Enoch, B Heldreth, B Hobocienski, K Muldoon-Jacobs, Y Lan, J C Madden and 16 more

Abstract read
In one paragraph

Article in Computational toxicology (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Paths to cheminformatics: Q&A with Ann M. Richard.Journal of cheminformatics · 2023
    Article
  6. Article
  7. Article
  8. The chemical landscape of high-throughput new approach methodologies for exposure.Journal of exposure science & environmental epidemiology · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

C YangMN-AM, Columbus, OH, USA.
M T D CroninSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, UK.
K B ArvidsonUS FDA CFSAN College Park, MD, USA.
B BienfaitMN-AM Nürnberg, Germany.
S J EnochSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, UK.
B HeldrethCosmetic Ingredient Review, Washington, DC, USA.
B HobocienskiMN-AM, Columbus, OH, USA.
K Muldoon-JacobsUS FDA CFSAN College Park, MD, USA.
Y LanUniversity of Bradford, UK.
J C MaddenSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, UK.
T MagdziarzMN-AM Nürnberg, Germany.
J MarusczykMN-AM Nürnberg, Germany.
A MostragMN-AM, Columbus, OH, USA.
M NelmsSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, UK.
D NeaguUniversity of Bradford, UK.
K PrzybylakSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, UK.
J F RathmanMN-AM, Columbus, OH, USA.
J ParkMN-AM, Columbus, OH, USA.
A-N RicharzSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, UK.
A M RichardUS EPA RTP, NC, USA.
J V RibeiroMN-AM, Columbus, OH, USA.
O SacherMN-AM Nürnberg, Germany.
C SchwabMN-AM Nürnberg, Germany.
V VitchevaMN-AM, Columbus, OH, USA.
P VolarathUS FDA CFSAN College Park, MD, USA.
A P WorthEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COSMOS Database (DB) was originally established to provide reliable data for cosmetics-related chemicals within the COSMOS Project funded as part of the SEURAT-1 Research Initiative. The database has subsequently been maintained and developed further into COSMOS Next Generation (NG), a combination of database and

Indexed as

Analogue selectionAOP, Adverse Outcome PathwayCERES, Chemical Evaluation and Risk Estimation SystemCFSAN, Center for Food Safety and Applied NutritionCMS-ID, COSMOS Identification NumberCosIng, Cosmetic Ingredient DatabaseCOSMOS DB, COSMOS DatabaseCOSMOS MINIS, Minimum Inclusion Criteria of Studies in COSMOS DBCOSMOS NG, COSMOS Next GenerationCRADA, Cooperative Research and Development AgreementDART, Developmental & Reproductive ToxicityDatabaseDB, DatabaseDST, Dempster Shafer TheoryECHA, European Chemicals AgencyEFSA, European Food Safety AuthorityGuided workflowHESS, Hazard Evaluation Support SystemHNEL, Highest No Effect LevelHTS, High throughput screeningILSI, International Life Sciences InstituteIUCLID, International Uniform Chemical Information DatabaseKnowledge hubLEL, Lowest Effect LevelLOAEL, Lowest Observed Adverse Effect LevelLogP, Logarithm of the octanol:water partition coefficientNAM, New Approach MethodologyNGRA, Next Generation Risk-AssessmentNITE, National Institute of Technology and Evaluation (Japan)NOAEL, No Observed Adverse Effect LevelNTP, National Toxicology ProgramOECD, Organisation for Economic Co-operation and DevelopmentOpenFoodTox, EFSA’s OpenFoodTox databasePAFA, Priority-based Assessment of Food Additive databasePK/TK, Pharmacokinetics/ToxicokineticsPublic databaseQA, Quality AssuranceQC, Quality ControlREACH, Registration, Evaluation, Authorisation and Restriction of ChemicalsSCCNFP, Scientific Committee of Cosmetic Products and Non-food Products intended for Consumers (EU)SCCP, Scientific Committee on Consumer Products (EU)SCC, Science Committee on Cosmetics (EU)SCCS, Scientific Committee on Consumer Safety (EU)Study reliabilityToxicityToxRefDB, Toxicity Reference DatabaseTTC, Threshold of Toxicological ConcernUS EPA, United States Environmental Protection AgencyUS FDA, United States Food and Drug Administration

Identifiers

PMID34405124
PMCPMC8351204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.