ArticleMovement disorders clinical practice2021
The Spectrum of Movement Disorders in Cases with Osmotic Demyelination Syndrome.
Article in Movement disorders clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Movement disorder emergencies at a tertiary-care center in West Bengal, India: Spectrum, etiologies, diagnostic implications.Next research · 2026Article
- Two Novel Movement Disorders with Osmotic Demyelination Syndrome.Movement disorders clinical practice · 2025Article
- PRES or ODS: An atypical presentation of osmotic demyelination syndrome?Radiology case reports · 2025Article
- Unmasking Osmotic Demyelination Syndrome/Extrapontine Myelinolysis in Acute Intermittent Porphyria: Preventable Complications-Challenges in Diagnosis and Management.Annals of Indian Academy of Neurology · 2025Article
- The role of presynaptic dopaminergic imaging in acquired neurological conditions affecting basal ganglia: a systematic review.Frontiers in neurology · 2025Review
- A Case Report in the Management of Dysphagia in Osmotic Demyelination Syndrome Using Mann Assessment of Swallowing Ability (MASA).Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- The Response of Osmotic Demyelination Syndrome to Plasmapheresis in a Patient Presenting with Catatonia after Correction of Hyponatraemia in Hyperemesis Gravidarum.European journal of case reports in internal medicine · 2024Article
- Secondary parkinsonism associated with focal brain lesions.Frontiers in neurology · 2024Review
- Osmotic demyelination syndrome after liver transplantation: A case report and an updated review.Saudi journal of anaesthesiaArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsmotic demyelination syndrome (ODS) can be a central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) based on the regions involved even though they share the same disease process, aetiopathogenesis and time course.
objectivesPresent study aims to characterize the clinical, radiological features and the outcome of patients with ODS with movement disorders as the forthcoming manifestation.
methodsChart review of patients with ODS with movement disorders. Demographic, clinical and radiological details of the patients were reviewed.
resultsEleven patients (six females; mean age: 48.3 ± 17.6 years) were included in the study. Parkinsonism alone and parkinsonism with dystonia was noted in four patients each (36.4%) while dystonia alone was noted in the other 3 (27.3%). Five patients (45.5%) had postural tremors. While 5 patients had dystonia early in the course of illness (3-7 days), it was delayed (6-9 months) in the other 2. A triphasic course was noted in two patients. The first phase of hyponatremia induced neurological impairment was followed by a second phase of worsening due to the immediate effect of ODS and a third delayed phase of worsening due to delayed effect of ODS. MRI showed both EPM and CPM in eight patients, EPM alone in two patients and CPM alone in 1 patient. Nine patients had a good outcome with mRS < 3.
conclusionParkinsonism and dystonia are important manifestations of ODS. Triphasic course with a delayed phase of worsening of movement disorders is probably due to the maladaptive neuronal repair. The concept of triphasic ODS is first being described in our series.
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