Evidence map›Paper›PMID 34405093›Full record

ArticleOpen forum infectious diseases2021

Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019.

Emma D Bainbridge, Priscilla Y Hsue, Jonathan H Esensten, Kara L Lynch, Carolyn M Hendrickson, Sarah B Doernberg, Monica Fung, Peter Chin-Hong, Clara Di Germanio, Philip J Norris and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Lessons learned from the use of convalescent plasma for the treatment of COVID-19 and specific considerations for immunocompromised patients.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2022
    Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emma D BainbridgeDivision of Infectious Diseases, University of California San Francisco, San Francisco, California, USA.
Priscilla Y HsueDivision of Cardiology, Zuckerberg San Francisco General, University of California San Francisco, San Francisco, California, USA.
Jonathan H EsenstenDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
Kara L LynchDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
Carolyn M HendricksonDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, California, USA.
Sarah B DoernbergDivision of Infectious Diseases, University of California San Francisco, San Francisco, California, USA.
Monica FungDivision of Infectious Diseases, University of California San Francisco, San Francisco, California, USA.
Peter Chin-HongDivision of Infectious Diseases, University of California San Francisco, San Francisco, California, USA.
Clara Di GermanioVitalant Research Institute, San Francisco, California, USA.
Philip J NorrisDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
Graham SimmonsDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
David V GliddenDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Anne F LuetkemeyerDivision of HIV, Infectious Diseases and Global Medicine, Zuckerberg San Francisco General, University of California San Francisco, San Francisco, California, USA.

Funding

Role of Hematopoietic System and Proteomics in HIV-Associated CardiovascularDiseaseK24AI112393 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSUE, PRISCILLA Y. · 2014 to 2024
$1.9M
Acute Respiratory Distress Syndrome after Isolated Traumatic Brain Injury: Platelet Biology, Endothelial Activation, and Mechanical VentilationK23HL133495 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HENDRICKSON, CAROLYN MARIE · 2016 to 2020
$994k
NHLBI NIH HHS K23 HL133495NIAID NIH HHS K24 AI112393
6 · The paper itself

Abstract

We characterized the antibody composition of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) and the immunologic responses of hospitalized COVID-19 patients after receiving CCP or nonimmune fresh frozen plasma. Despite selection of CCP with significantly higher total immunoglobulin G than recipients, neutralizing antibody levels did not differ between donor plasma and CCP recipients.

Indexed as

antibody avidityconvalescent plasmaCOVID-19neutralizing antibodySARS-CoV-2

Identifiers

PMID34405093
PMCPMC8344822

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.