Evidence map›Paper›PMID 34404993›Full record

ArticleJournal of geriatric cardiology : JGC2021

Vulnerable atherosclerotic plaque features: findings from coronary imaging.

Osamu Kurihara, Masamichi Takano, Yasushi Miyauchi, Kyoichi Mizuno, Wataru Shimizu

Open access · greenAbstract read
In one paragraph

Article in Journal of geriatric cardiology : JGC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Endothelial Surface Glycocalyx in Vascular Functions and Diseases.Advances in experimental medicine and biology · 2026
    Review
  2. Review
  3. Optical Coherence Tomography in Acute Coronary Syndromes.Reviews in cardiovascular medicine · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. [Numerical simulation study of fracture mechanics of the atherosclerotic plaque].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Osamu KuriharaCardiovascular Center, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.
Masamichi TakanoCardiovascular Center, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.
Yasushi MiyauchiCardiovascular Center, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.
Kyoichi MizunoMitsukoshi Health and Welfare Foundation, Tokyo, Japan.
Wataru ShimizuDivision of Cardiology, Nippon Medical School, Tokyo, Japan.
Chiba Hokusou Hospital · JPMitsukoshi Health and Welfare Foundation · JPNippon Medical School · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathological studies have suggested that features of vulnerable atherosclerotic plaques likely to progress and lead to acute cardiovascular events have specific characteristics. Given the progress of intravascular coronary imaging technology, some large prospective studies have detected features of vulnerable atherosclerotic plaques using these imaging modalities. However, the rate of cardiovascular events, such as acute coronary syndrome, has been found to be considerably reduced in the limited follow-up period available in the statin era. Additionally, not all disrupted plaques lead to thrombus formation with clinical presentation. If sub-occlusive or occlusive thrombus formation does not occur, a thrombus on a disrupted plaque will organize without any symptoms, forming a "healed plaque". Although vulnerable plaque detection using intracoronary imaging is focused on "thin-cap fibroatheroma" leading to plaque rupture, superficial plaque erosion is increasingly recognized; however, the underlying mechanism of thrombus formation on eroded plaques is not well understood. One of intravascular imaging, optical coherence tomography (OCT) has the highest image resolution and has enabled detailed characterization of the plaque

Identifiers

PMID34404993
PMCPMC8352771
OpenAlexW3180137962

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.