ArticleJournal of geriatric cardiology : JGC2021
Association between coronary artery calcification and cognitive function in a Chinese community-based population.
Article in Journal of geriatric cardiology : JGC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Coronary Artery Calcium and Cognitive Decline in the Diabetes Prevention Program Outcomes Study.Journal of the American Heart Association · 2023Trial
- Coronary Artery Calcium Progression and Cognitive Function in Midlife-The Coronary Artery Risk Development in Young Adults (CARDIA) Study.Circulation. Population health and outcomes · 2026Article
- Association of abdominal aortic calcification with cognitive impairment in peritoneal dialysis patients.BMC nephrology · 2025Article
- Genomic Characterisation of the Relationship and Causal Links Between Vascular Calcification, Alzheimer's Disease, and Cognitive Traits.Biomedicines · 2025Article
- Associations Between Atherosclerosis and Subsequent Cognitive Decline: A Prospective Cohort Study.Journal of the American Heart Association · 2024Article
- Beyond the Heart: The Predictive Role of Coronary Artery Calcium Scoring in Non-Cardiovascular Disease Risk Stratification.Diagnostics (Basel, Switzerland) · 2024Review
- Association between Serum Cystatin C levels and long-term cardiovascular outcomes and all-cause mortality in older patients with obstructive sleep apnea.Frontiers in physiology · 2022Article
- Associations between abdominal obesity and the risk of stroke in Chinese older patients with obstructive sleep apnea: Is there an obesity paradox?Frontiers in aging neuroscience · 2022Article
- [Correlation of obstructive sleep apnea with components of metabolic syndrome and implications for long-term adverse cardiovascular risk in elderly patients].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Impact of obstructive sleep apnea complicated with type 2 diabetes on long-term cardiovascular risks and all-cause mortality in elderly patients.BMC geriatrics · 2021Article
- Association of Metabolic Syndrome With Long-Term Cardiovascular Risks and All-Cause Mortality in Elderly Patients With Obstructive Sleep Apnea.Frontiers in cardiovascular medicine · 2021Article
- The short-term impacts of COVID-2019 on depressive symptoms and cognitive decline: A community-based cohort study.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary atherosclerosis and cognitive impairment are both age-related diseases, with similar risk factors. Coronary artery calcium (CAC), a marker of coronary atherosclerosis, may play a role in early detection of individuals prone to cognitive decline. This study aimed to investigate the relationship between CAC and cognitive function, and the capability of CAC to identify participants with a high risk of dementia in a Chinese community-based population.
methodsA total of 1332 participants, aged 40-80 years and free of dementia from a community located in Beijing were included. All participants completed neurocognitive questionnaires and noncontrast CT examinations. Cognitive performance tests (including verbal memory, semantic fluency, executive function, and global cognitive function tests), the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CIDE) risk score, and the CAC score (CACS) were evaluated by questionnaires and CT. A CAIDE score ≥ 10 was considered to indicate a high risk of dementia in late-life. Participants were divided into three groups according to CACS (0, 1-399, ≥ 400).
resultsAfter adjusting for risk factors, CACS was significantly associated with verbal memory (
conclusionsCAC, a marker of subclinical atherosclerosis, was significantly associated with cognitive performance in verbal memory and global cognitive function. CAC had a moderate capability to identify participants with a high risk of dementia, independent of age, education, and other risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.