Evidence map›Paper›PMID 34404938›Full record

ArticleNature reviews. Endocrinology2021

A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus.

Gaowei Wang, Maike Sander

Abstract readComment
PubMed Publisher
In one paragraph

Article in Nature reviews. Endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Gaowei WangDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California San Diego, La Jolla, CA, USA.
Maike SanderDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California San Diego, La Jolla, CA, USA. masander@ucsd.edu.ORCID http://orcid.org/0000-0001-5308-7785

Funding

Nkx6 gene function in pancreas developmentR01DK068471 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI WORTHAM, MATTHEW · 2004 to 2024
$6.6M
Genetic mechanisms of type 1 diabetes risk in stress-induced pancreatic isletsR01DK122607 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAULTON, KYLE JEFFRIE · 2019 to 2022
$4.4M
Novel insights into nutrient-dependent regulation of beta cell proliferationR01DK078803 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDER, MAIKE · 2007 to 2022
$4.4M
Single cell analysis of the human pancreas in type 1 diabetesU01DK120429 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAULTON, KYLE JEFFRIE, SANDER, MAIKE · 2018 to 2021
$3.1M
A 3D vascularized islet biomimetic to model type 1 diabetesUG3DK122639 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUGHES, CHRISTOPHER C. W., SANDER, MAIKE · 2019 to 2020
$2.1M
Promotion of beta cell proliferation by epigenetically reprogrammed macrophagesR01DK114427 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDER, MAIKE · 2018 to 2022
$1.9M
NIDDK NIH HHS R01 DK068471NIDDK NIH HHS R01 DK078803NIDDK NIH HHS R01 DK114427NIDDK NIH HHS R01 DK122607NIDDK NIH HHS U01 DK120429NIDDK NIH HHS UG3 DK122639
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Insulin-Secreting CellsHumans

Identifiers

PMID34404938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.