ArticleEuropean journal of clinical nutrition2022
The associations between whole grain and refined grain intakes and serum C-reactive protein.
Article in European journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Postprandial Effects of Four Test Meals Containing Wholegrain Rye or Refined Wheat Foods on Circulating Incretins, Ghrelin, Glucose, and Inflammatory Markers.The Journal of nutrition · 2025Trial
- Reduced Neuroinflammation and Pain with a Functional Sourdough Bread Enriched with Legumes and Ancient Cereals in a Mouse Model of LPS-Induced Inflammation.International journal of molecular sciences · 2026Article
- Inflammation-oriented dietary pattern and menopause timing in postmenopausal women: evidence from the Health and Retirement Study.Frontiers in nutrition · 2026Article
- The association between a pro-inflammatory diet and brain age in middle-aged and older adults.European journal of epidemiology · 2026Article
- Food groups and micronutrients associated with chemotherapy-induced peripheral neuropathy in survivors of cancer post-neurotoxic treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Leisure activity engagement attenuates the risks of cognitive impairment induced by unhealthy plant-based diets: a nationwide cohort study.European journal of clinical nutrition · 2025Article
- Food Quality Is Associated With Depression, Anxiety, and Stress Among Recovered COVID-19 Patients: Finding From a Case-Control Study.Clinical nutrition research · 2025Article
- Whole grains temper immune-mediated inflammation in Chinese esophageal squamous-cell carcinoma survivors: a multicenter questionnaire study.Frontiers in immunology · 2025Article
- Composition of Whole Grain Dietary Fiber and Phenolics and Their Impact on Markers of Inflammation.Nutrients · 2024Review
- Association of Dietary Fiber and Measures of Physical Fitness with High-Sensitivity C-Reactive Protein.Nutrients · 2024Article
- Whole grain intake, diet quality and risk factors of chronic diseases: results from a population-based study in Finnish adults.European journal of nutrition · 2024Article
- Associations between healthy food groups and platelet-activating factor, lipoprotein-associated phospholipase AEuropean journal of nutrition · 2024Article
- Obesity-associated inflammation countered by a Mediterranean diet: the role of gut-derived metabolites.Frontiers in nutrition · 2024Review
- Association of the Korean-specific food-based index of dietary inflammatory potential with the risk of mild cognitive impairment in Korean older adults.Epidemiology and health · 2024Article
- Impact of Dietary Quality on Genital Oncogenic Human Papillomavirus Infection in Women.The Journal of infectious diseases · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesEpidemiological studies suggest that whole grain intake has inverse associations with low-grade inflammation, but findings regarding refined grains are inconclusive. Our objective was to investigate whether consumption of whole or refined grains is associated with serum high sensitivity CRP (hs-CRP). SUBJECTS/
methodsThe study included 756 generally healthy men and women aged 53-73 years from the Kuopio Ischaemic Heart Disease Risk Factory Study, examined in 1999-2001. Dietary intakes were assessed using 4-day food records. ANCOVA and linear regression were used for analyses.
resultsThe mean intake of whole and refined grains was 136 g/day (SD 80) and 84 g/day (SD 46), respectively. Higher whole grain intake was associated with lower hs-CRP concentration and higher refined grain intake with higher concentration after adjustment for lifestyle and dietary factors. Each 50 g/d higher whole grain intake was associated with 0.12 mg/L (95% Cl 0.02-0.21 mg/L) lower hs-CRP concentration and each 50 g/d higher refined grain intake with 0.23 mg/L (95% Cl 0.08-0.38) higher concentration. Adjustment for fibre from grains attenuated the associations especially with whole grains. There were no statistically significant interactions according to gender or BMI (P for interactions >0.065).
conclusionsThe results of this study suggest that higher intake of whole grains is associated with lower concentrations of hs-CRP and higher intake of refined grains is associated with higher concentrations. However, especially the association with whole grain intake was attenuated after adjusting for fibre intake from grains, suggesting that cereal fibre may partly explain the association.
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