ArticleScientific reports2021
Handheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Handheld laser speckle contrast imaging probe: quantitative video rate assessment of tissue perfusion in animal and patient applications.Biophotonics discovery · 2025Article
- Enhancement of vascular visualization in laser speckle contrast imaging based on image algorithms.Journal of biomedical optics · 2025Article
- Lightweight denoising speckle contrast image GAN for real-time denoising of laser speckle imaging of blood flow.Biomedical optics express · 2025Article
- Patient-specific arterial input function for accurate perfusion assessment in intraoperative fluorescence imaging.Journal of biomedical optics · 2024Article
- Applications of Laser Speckle Contrast Imaging Technology in Dermatology.JID innovations : skin science from molecules to population health · 2023Review
- Prediction of motion artifacts caused by translation in handheld laser speckle contrast imaging.Journal of biomedical optics · 2023Article
- Perfusion measured by laser speckle contrast imaging as a predictor for expansion of psoriasis lesions.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enabling handheld perfusion imaging would drastically improve the feasibility of perfusion imaging in clinical practice. Therefore, we examine the performance of handheld laser speckle contrast imaging (LSCI) measurements compared to mounted measurements, demonstrated in psoriatic skin. A pipeline is introduced to process, analyze and compare data of 11 measurement pairs (mounted-handheld LSCI modes) operated on 5 patients and various skin locations. The on-surface speeds (i.e. speed of light beam movements on the surface) are quantified employing mean separation (MS) segmentation and enhanced correlation coefficient maximization (ECC). The average on-surface speeds are found to be 8.5 times greater in handheld mode compared to mounted mode. Frame alignment sharpens temporally averaged perfusion maps, especially in the handheld case. The results show that after proper post-processing, the handheld measurements are in agreement with the corresponding mounted measurements on a visual basis. The absolute movement-induced difference between mounted-handheld pairs after the background correction is [Formula: see text] (mean ± std, [Formula: see text]), with an absolute median difference of [Formula: see text]. Realization of handheld LSCI facilitates measurements on a wide range of skin areas bringing more convenience for both patients and medical staff.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.