Evidence map›Paper›PMID 34404865›Full record

ArticleScientific reports2021

Molecular remission at T cell level in patients with rheumatoid arthritis.

Jun Inamo, Katsuya Suzuki, Masaru Takeshita, Yasushi Kondo, Yuumi Okuzono, Keiko Koga, Yoshiaki Kassai, Maiko Takiguchi, Rina Kurisu, Akihiko Yoshimura and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 37 citations in OpenAlex.

  1. Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes.Clinical reviews in allergy & immunology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Resolution of inflammation during rheumatoid arthritis.Frontiers in cell and developmental biology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jun InamoDivision of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Katsuya SuzukiDivision of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Masaru TakeshitaDivision of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Yasushi KondoDivision of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Yuumi OkuzonoImmunology Unit, Takeda Pharmaceutical Co Ltd, Fujisawa-Shi, ResearchKanagawa, Japan.
Keiko KogaImmunology Unit, Takeda Pharmaceutical Co Ltd, Fujisawa-Shi, ResearchKanagawa, Japan.
Yoshiaki KassaiImmunology Unit, Takeda Pharmaceutical Co Ltd, Fujisawa-Shi, ResearchKanagawa, Japan.
Maiko TakiguchiImmunology Unit, Takeda Pharmaceutical Co Ltd, Fujisawa-Shi, ResearchKanagawa, Japan.
Rina KurisuImmunology Unit, Takeda Pharmaceutical Co Ltd, Fujisawa-Shi, ResearchKanagawa, Japan.
Akihiko YoshimuraDepartment of Microbiology and Immunology, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
Tsutomu TakeuchiDivision of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. tsutake@z5.keio.jp.
Keio University · JPTakeda (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While numerous disease-modifying anti-rheumatic drugs (DMARDs) have brought about a dramatic paradigm shift in the management of rheumatoid arthritis (RA), unmet needs remain, such as the small proportion of patients who achieve drug-free status. The aim of this study was to explore key molecules for remission at the T cell level, which are known to be deeply involved in RA pathogenesis, and investigate the disease course of patients who achieved molecular remission (MR). We enrolled a total of 46 patients with RA and 10 healthy controls (HCs). We performed gene expression profiling and selected remission signature genes in CD4

Indexed as

TranscriptomeArthritis, RheumatoidCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCross-Sectional StudiesHumansMachine LearningRemission Induction

Identifiers

PMID34404865
PMCPMC8371080
OpenAlexW3165226956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.