ArticleScientific reports2021
The ABCC4 gene is associated with pyometra in golden retriever dogs.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Uterine Dysfunctions in Non-Pregnant and Pregnant Small Animals.Reproduction in domestic animals = Zuchthygiene · 2026Review
- Pyometra with Concurrent Endometrial Adenocarcinoma in Laboratory Opossums (Monodelphis domestica): A Case Series of Four Animals.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Predisposing Factors for Pseudoplacentational Endometrial Hyperplasia or Cystic Endometrial Hyperplasia in Dogs and Their Association with Pyometra.Veterinary sciences · 2024Article
- Genome wide association study in Swedish Labrador retrievers identifies genetic loci associated with hip dysplasia and body weight.Scientific reports · 2024Article
- Canine Pyometra: A Short Review of Current Advances.Animals : an open access journal from MDPI · 2023Review
- Drug Discovery in Canine Pyometra Disease Identified by Text Mining and Microarray Data Analysis.BioMed research international · 2023Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyometra is one of the most common diseases in female dogs, presenting as purulent inflammation and bacterial infection of the uterus. On average 20% of intact female dogs are affected before 10 years of age, a proportion that varies greatly between breeds (3-66%). The clear breed predisposition suggests that genetic risk factors are involved in disease development. To identify genetic risk factors associated with the disease, we performed a genome-wide association study (GWAS) in golden retrievers, a breed with increased risk of developing pyometra (risk ratio: 3.3). We applied a mixed model approach comparing 98 cases, and 96 healthy controls and identified an associated locus on chromosome 22 (p = 1.2 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.