ArticleScientific reports2021
New loci and neuronal pathways for resilience to heat stress in cattle.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 85 citations in OpenAlex.
- Effects of the Temperature-Humidity Index on Milk Production Traits and Gene-Environment Interactions in Chinese Holstein Cows.Animals : an open access journal from MDPI · 2026Article
- Consequences of Heat Stress on Physiology, Microbiome Dynamics, and Multi-Omics in Dairy Cows: More than Meets the Eye.Biology · 2026Review
- Genome-Wide Association Studies of Milk Composition Traits in Holstein Cattle Raised in Tropical and Subtropical Conditions.Animals : an open access journal from MDPI · 2026Article
- Integrating Precision Livestock Farming and Genomic Tools for Heat Stress Mitigation in South African Dairy Cattle.Animals : an open access journal from MDPI · 2026Review
- The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution.Animals : an open access journal from MDPI · 2026Review
- Precision livestock farming and integrated molecular profiling reveal heat-stress resilience signatures in Marchigiana cattle.Frontiers in veterinary science · 2026Article
- Life History and Smoltification Shape Genomic Signatures of Thermal Tolerance in Chinook Salmon.Molecular ecology · 2026Article
- Integrating extensive functional annotations and multiomics of cattle enhances climate resilience prediction and mapping.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Candidate gene search for milk production and composition, milk coagulation properties, and milk protein profile in dairy sheep from a New Zealand flock.Animal biotechnology · 2025Article
- Comparison between SNP array and imputed data to estimate population structure and ROH hotspots in horse breeds.BMC genomics · 2025Article
- Genome-environment association analysis reveals climate-driven adaptation of chickens.Genetics, selection, evolution : GSE · 2025Article
- Identification of single nucleotide polymorphisms (SNPs) associated with heat stress and milk production traits in Chinese holstein cows.BMC genomics · 2025Article
- Short communication: relationships between novel breeding values for heat tolerance and rectal temperature during heat stress in lactating Holstein cows.Journal of animal science · 2025Article
- Article
- Integrating Genomic Selection and a Genome-Wide Association Study to Improve Days Open in Thai Dairy Holstein Cattle: A Comprehensive Genetic Analysis.Animals : an open access journal from MDPI · 2024Article
- Genomic Analysis of Sarda Sheep Raised at Diverse Temperatures Highlights Several Genes Involved in Adaptations to the Environment and Heat Stress Response.Animals : an open access journal from MDPI · 2024Article
- Capturing resilience from phenotypic deviations: a case study using feed consumption and whole genome data in pigs.BMC genomics · 2024Article
- Impact of Heat Stress on Milk Yield, Milk Fat-to-Protein Ratio, and Conception Rate in Thai-Holstein Dairy Cattle: A Phenotypic and Genetic Perspective.Animals : an open access journal from MDPI · 2024Article
- Functional transcriptome analysis revealed major changes in pathways affecting systems biology of Tharparkar cattle under seasonal heat stress.3 Biotech · 2024Article
- Genomic analyses of withers height and linear conformation traits in German Warmblood horses using imputed sequence-level genotypes.Genetics, selection, evolution : GSE · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While understanding the genetic basis of heat tolerance is crucial in the context of global warming's effect on humans, livestock, and wildlife, the specific genetic variants and biological features that confer thermotolerance in animals are still not well characterized. We used dairy cows as a model to study heat tolerance because they are lactating, and therefore often prone to thermal stress. The data comprised almost 0.5 million milk records (milk, fat, and proteins) of 29,107 Australian Holsteins, each having around 15 million imputed sequence variants. Dairy animals often reduce their milk production when temperature and humidity rise; thus, the phenotypes used to measure an individual's heat tolerance were defined as the rate of milk production decline (slope traits) with a rising temperature-humidity index. With these slope traits, we performed a genome-wide association study (GWAS) using different approaches, including conditional analyses, to correct for the relationship between heat tolerance and level of milk production. The results revealed multiple novel loci for heat tolerance, including 61 potential functional variants at sites highly conserved across 100 vertebrate species. Moreover, it was interesting that specific candidate variants and genes are related to the neuronal system (ITPR1, ITPR2, and GRIA4) and neuroactive ligand-receptor interaction functions for heat tolerance (NPFFR2, CALCR, and GHR), providing a novel insight that can help to develop genetic and management approaches to combat heat stress.
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