ArticleNature communications2021
Phylogenomics of a new fungal phylum reveals multiple waves of reductive evolution across Holomycota.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed.
- The Origin and Early Evolution of Fungi: Challenges, Inferences, and Principles.Annual review of cell and developmental biology · 2026Review
- Comprehensive analysis of small GTPases in Microsporidia reveals new extremes in eukaryotic cell biology.BMC biology · 2026Article
- Re-shaping the family-level classification ofStudies in mycology · 2026Article
- The diversity and abundance of chytrids on the Greenland Ice Sheet.Scientific reports · 2026Article
- Article
- Dynamic remodeling of centrioles and the microtubule cytoskeleton in the lifecycle of chytrid fungi.Molecular biology of the cell · 2025Article
- A timetree of Fungi dated with fossils and horizontal gene transfers.Nature ecology & evolution · 2025Article
- A genomic perspective on fungal diversity and evolution.Nature reviews. Microbiology · 2025Review
- Symmetric adenine methylation is an essential DNA modification in the early-diverging fungus Rhizopus microsporus.Nature communications · 2025Article
- A phylogenetic analysis of the CDKL protein family unravels its evolutionary history and supports theFrontiers in cell and developmental biology · 2025Article
- Thirty novel fungal lineages: formal description based on environmental samples and DNA.MycoKeys · 2025Article
- A taxon-rich and genome-scale phylogeny of Opisthokonta.PLoS biology · 2024Article
- Symmetric and asymmetric DNA N6-adenine methylation regulates different biological responses in Mucorales.Nature communications · 2024Article
- Dollo Parsimony Overestimates Ancestral Gene Content Reconstructions.Genome biology and evolution · 2024Article
- Exploring the prokaryote-eukaryote interplay in microbial mats from an Andean athalassohaline wetland.Microbiology spectrum · 2024Article
- Mitochondrial genomic characteristics and phylogenetic analysis of a brewing fungus,Mitochondrial DNA. Part B, Resources · 2024Article
- Characterization of the complete mitochondrial genome ofMitochondrial DNA. Part B, Resources · 2024Article
- Unveiling species diversity within early-diverging fungi from China I: three new species ofMycoKeys · 2024Article
- Respirable Metals, Bacteria, and Fungi during a Saharan-Sahelian Dust Event in Houston, Texas.Environmental science & technology · 2023Article
- Incongruence in the phylogenomics era.Nature reviews. Genetics · 2023Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Compared to multicellular fungi and unicellular yeasts, unicellular fungi with free-living flagellated stages (zoospores) remain poorly known and their phylogenetic position is often unresolved. Recently, rRNA gene phylogenetic analyses of two atypical parasitic fungi with amoeboid zoospores and long kinetosomes, the sanchytrids Amoeboradix gromovi and Sanchytrium tribonematis, showed that they formed a monophyletic group without close affinity with known fungal clades. Here, we sequence single-cell genomes for both species to assess their phylogenetic position and evolution. Phylogenomic analyses using different protein datasets and a comprehensive taxon sampling result in an almost fully-resolved fungal tree, with Chytridiomycota as sister to all other fungi, and sanchytrids forming a well-supported, fast-evolving clade sister to Blastocladiomycota. Comparative genomic analyses across fungi and their allies (Holomycota) reveal an atypically reduced metabolic repertoire for sanchytrids. We infer three main independent flagellum losses from the distribution of over 60 flagellum-specific proteins across Holomycota. Based on sanchytrids' phylogenetic position and unique traits, we propose the designation of a novel phylum, Sanchytriomycota. In addition, our results indicate that most of the hyphal morphogenesis gene repertoire of multicellular fungi had already evolved in early holomycotan lineages.
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