ArticleNature communications2021
Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 2 pooled it
10.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
115 citing papers in PubMed, 2 syntheses or guidelines pooled it, 175 citations in OpenAlex.
- Single-cell transcriptome landscape of circulating CD4Cell genomics · 2024Pooled it
- Research progress on the application of single-cell sequencing in autoimmune diseases.Genes and immunity · 2023Pooled it
- Senescent-like activated naive B cells contribute to progression to clinical rheumatoid arthritis.Nature aging · 2026Article
- Immune-mediated rheumatoid arthritis: from single-cell genomics to new therapies.Nature immunology · 2026Review
- Dysregulated IL-2 signaling and T-cell subset shifts are associated with eosinophilic esophagitis activity.Biochemistry and biophysics reports · 2026Article
- Exacerbation of inflammatory bone loss in TET2-driven clonal hematopoiesis.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Remnant cholesterol inflammation index (RCII) as a potential biomarker for ACPA-negative rheumatoid arthritis: evidence from dual-cohort analysis and serum lipidomics.Clinical rheumatology · 2026Article
- Multimodal Integration of Protein Interactomes With Genomic and Molecular Data Discovers Distinct Rheumatoid Arthritis Endotypes.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- scImmuneCo: a compendium of cell-type-specific functional modules for decoding immune responses from single-cell RNA-seq data.Briefings in bioinformatics · 2026Article
- Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis.Immunity · 2026Article
- Single-cell and spatial profiling of peripheral blood and synovium unveils pro-arthritis CNBPJournal of translational medicine · 2026Article
- A Comparative Single-Cell Atlas Reveals Pre-injury Signatures of Superior Healing in Oral Mucosa and Informing a New Paradigm for Wound Management.Functional & integrative genomics · 2026Article
- Rheumatoid arthritis and gout: a rare combination or overlooked coexistence?Arthritis research & therapy · 2026Article
- Article
- CellMap: precision mapping of cellular landscape in spatial transcriptomics.Nucleic acids research · 2026Article
- Immune dysregulation driven by elevated platelet-to-lymphocyte ratio aggravates myasthenia gravis.The Journal of international medical research · 2026Article
- MSC-derived microvesicles inhibit the progression of arthritis in a murine model of preclinical rheumatoid arthritis.Frontiers in immunology · 2026Article
- SYK Activation Enhances Dendritic Cell Functions in Spontaneous Rheumatoid Arthritis.Inflammation · 2025Article
- Seronegative Rheumatoid Arthritis: A Distinct Immunopathological Entity with Erosive Potential.Medical sciences (Basel, Switzerland) · 2025Review
- Targeted delivery of Prussian blue modified exosomes to CD90-expressing synovial fibroblasts for Rheumatoid arthritis immunotherapy.Materials today. Bio · 2025Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 4 institutions in 2 countries.
Xunyao Wu *Clinical Immunology Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yi Liu *Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, China.ORCID 0000-0003-2990-5738
Shanzhao Jin *Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, China.ORCID 0000-0003-3939-4978
Min Wang *Clinical Immunology Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yuhao JiaoClinical Immunology Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Bo YangDepartment of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xin LuDepartment of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xin JiClinical Immunology Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yunyun FeiDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, The Ministry of Education Key Laboratory, Beijing, China.
Huaxia YangDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, The Ministry of Education Key Laboratory, Beijing, China.
Lidan ZhaoDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, The Ministry of Education Key Laboratory, Beijing, China.
Hua ChenDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, The Ministry of Education Key Laboratory, Beijing, China.
Yaran ZhangClinical Immunology Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hao LiDivision of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Peter E LipskyRILITE Research Institute and AMPEL BioSolutions, Charlottesville, VA, USA.ORCID 0000-0002-9287-1676
George C TsokosDivision of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. gtsokos@bidmc.harvard.edu.ORCID 0000-0001-9589-2360
Fan BaiBiomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, China. fbai@pku.edu.cn.ORCID 0000-0001-6119-8936
Xuan ZhangDepartment of Rheumatology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China. zxpumch2003@sina.com.ORCID 0000-0001-8775-1699
Chinese Academy of Medical Sciences & Peking Union Medical College · CNPeking University · CNBeth Israel Deaconess Medical Center · USAmpel BioSolutions (United States) · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence or absence of anti-citrullinated peptide antibodies (ACPA) and associated disparities in patients with rheumatoid arthritis (RA) implies disease heterogeneity with unknown diverse immunopathological mechanisms. Here we profile CD45
Indexed as
Anti-Citrullinated Protein AntibodiesArthritis, RheumatoidAutoantibodiesCell LineChemokines, CCCohort StudiesGenetic Predisposition to DiseaseHLA-DR Serological SubtypesHumansKiller Cells, NaturalLeukocyte Common AntigensMatrix Metalloproteinase 3Monocyte Chemoattractant ProteinsMyeloid CellsSynovial MembraneT-LymphocytesAnti-Citrullinated Protein AntibodiesAutoantibodiesCCL13 protein, humanCCL18 protein, humanChemokines, CCHLA-DR15 antigenHLA-DR Serological SubtypesLeukocyte Common AntigensMatrix Metalloproteinase 3MMP3 protein, humanMonocyte Chemoattractant Proteins
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