ArticleNature communications2021
The physiological basis for contrast opponency in motion computation in Drosophila.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Imprecision in Vision: Lessons From Neural Circuits in the Fly.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Neural pathways and computations that achieve stable contrast processing tuned to natural scenes.Nature communications · 2024Article
- Article
- Heterogeneity of synaptic connectivity in the fly visual system.Nature communications · 2024Article
- Different spectral sensitivities of ON- and OFF-motion pathways enhance the detection of approaching color objects in Drosophila.Nature communications · 2023Article
- Neural mechanisms to incorporate visual counterevidence in self-movement estimation.Current biology : CB · 2023Article
- Article
- Article
- From Photons to Behaviors: Neural Implementations of Visual Behaviors inFrontiers in neuroscience · 2022Review
- Flexible filtering by neural inputs supports motion computation across states and stimuli.Current biology : CB · 2021Article
- The physiological basis for contrast opponency in motion computation in Drosophila.Nature communications · 2021Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In Drosophila, direction-selective neurons implement a mechanism of motion computation similar to cortical neurons, using contrast-opponent receptive fields with ON and OFF subfields. It is not clear how the presynaptic circuitry of direction-selective neurons in the OFF pathway supports this computation if all major inputs are OFF-rectified neurons. Here, we reveal the biological substrate for motion computation in the OFF pathway. Three interneurons, Tm2, Tm9 and CT1, provide information about ON stimuli to the OFF direction-selective neuron T5 across its receptive field, supporting a contrast-opponent receptive field organization. Consistent with its prominent role in motion detection, variability in Tm9 receptive field properties transfers to T5, and calcium decrements in Tm9 in response to ON stimuli persist across behavioral states, while spatial tuning is sharpened by active behavior. Together, our work shows how a key neuronal computation is implemented by its constituent neuronal circuit elements to ensure direction selectivity.
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