ArticleProceedings of the National Academy of Sciences of the United States of America2021
Parallel hippocampal-parietal circuits for self- and goal-oriented processing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024875 (Precision Neuroimaging of Parkinson's Disease), which is not on this map. Cited by 51 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Precision Neuroimaging of Parkinson's Disease
Who cites it
51 citing papers in PubMed.
- Trial
- Functional Imaging of Hippocampal Layers Using VASO and BOLD on the Next Generation (NexGen) 7T Scanner.Human brain mapping · 2026Article
- Phylogeny of Cortical-Hippocampal Projections Reveals Selective Elimination of Input From Sensory Regions.Hippocampus · 2026Article
- Female vulnerability to microvascular transport dysfunction emerges early across the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neural correlates of pure apathy in multiple sclerosis: An exploratory neuroimaging study.Journal of neuropsychology · 2026Article
- Electrophysiological dissociation of human posterior cingulate cortex contributions to value- and memory-based decision-making.bioRxiv : the preprint server for biology · 2026Article
- The hippocampus becomes topographically and functionally specialized along the longitudinal axis with development.Nature communications · 2026Article
- Trajectories of hippocampal subregion development in the first years of life and their association with school-aged episodic memory outcomes.bioRxiv : the preprint server for biology · 2026Article
- Parallel processing chains span cytoarchitectures to organize association cortex.bioRxiv : the preprint server for biology · 2026Article
- Spatial and semantic memory reorganize a hippocampal long-axis gradient.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Resting-state functional connectivity of hippocampal subregions in predicting escitalopram treatment outcome in major depressive disorder.Frontiers in psychiatry · 2026Article
- Dense Phenotyping of Human Brain Network Organization Using Precision fMRI.Annual review of psychology · 2026Review
- Article
- Graded encoding of spatial novelty scales in the human brain.Nature communications · 2025Article
- Old-New Recognition Memory Revisited.bioRxiv : the preprint server for biology · 2025Article
- Parallel systems for social and spatial cognition reaching the cortical apex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Spatial and semantic memory reorganize a hippocampal long-axis gradient.bioRxiv : the preprint server for biology · 2025Article
- The intrinsic time tracker: temporal context is embedded in entorhinal and hippocampal functional connectivity patterns.Nature communications · 2025Article
- Microstructural Changes in Aging Hippocampal Pathways: Insights From the HCP-Aging Diffusion MRI Study.Human brain mapping · 2025Article
- Functions of the posterior cingulate cortex and default network.Current opinion in behavioral sciences · 2025Article
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
The hippocampus is critically important for a diverse range of cognitive processes, such as episodic memory, prospective memory, affective processing, and spatial navigation. Using individual-specific precision functional mapping of resting-state functional MRI data, we found the anterior hippocampus (head and body) to be preferentially functionally connected to the default mode network (DMN), as expected. The hippocampal tail, however, was strongly preferentially functionally connected to the parietal memory network (PMN), which supports goal-oriented cognition and stimulus recognition. This anterior-posterior dichotomy of resting-state functional connectivity was well-matched by differences in task deactivations and anatomical segmentations of the hippocampus. Task deactivations were localized to the hippocampal head and body (DMN), relatively sparing the tail (PMN). The functional dichotomization of the hippocampus into anterior DMN-connected and posterior PMN-connected parcels suggests parallel but distinct circuits between the hippocampus and medial parietal cortex for self- versus goal-oriented processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.