Evidence map›Paper›PMID 34404727›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Nerea Llamosas, Sheldon D Michaelson, Thomas Vaissiere, Camilo Rojas, Courtney A Miller, Gavin Rumbaugh

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  8. bioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Review
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  12. Interneuron-Targeted Disruption ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nerea LlamosasDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458.
Sheldon D MichaelsonDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458.
Thomas VaissiereDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458.
Camilo RojasDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458.
Courtney A MillerDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458.
Gavin RumbaughDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458; grumbaug@scripps.edu.ORCID 0000-0001-6360-3894
Scripps Research Institute · US

Funding

Intersection of causal neurodevelopmental disorder risk genes, cortical circuit function, and cognitive processing required for behavioral adaptionsR01MH096847 · NIMH · UNIVERSITY OF FLORIDA · PI Courtney A Miller, GAVIN R RUMBAUGH · 2012 to 2026
$10.4M
Regulation of Memory Formation by the GTPase-activating Protein SynGAPR01NS064079 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RUMBAUGH, GAVIN R · 2009 to 2017
$3.9M
Evaluation of novel biomarkers of cognition in a model of sporadic developmental brain disorders and their application in efficacy testing of Ras pathway inhibitorsR01MH108408 · NIMH · SCRIPPS FLORIDA · PI RUMBAUGH, GAVIN R · 2015 to 2019
$3.3M
Causal Interactions between genetic risk, precise cortical connectivity, and autism-associated behaviorsR01NS110307 · NINDS · UNIVERSITY OF FLORIDA · PI RUMBAUGH, GAVIN R · 2020 to 2024
$2.6M
NIMH NIH HHS R01 MH096847NIMH NIH HHS R01 MH108408NINDS NIH HHS R01 NS064079NINDS NIH HHS R01 NS110307
6 · The paper itself

Abstract

A significant proportion of autism risk genes regulate synapse function, including plasticity, which is believed to contribute to behavioral abnormalities. However, it remains unclear how impaired synapse plasticity contributes to network-level processes linked to adaptive behaviors, such as experience-dependent ensemble plasticity. We found that

Indexed as

TouchAnimalsAutistic DisorderCerebral CortexEpigenesis, GeneticFemaleHumansMaleMiceNeuronal PlasticityNeuronsPatch-Clamp Techniquesras GTPase-Activating ProteinsSynapsesVibrissaeras GTPase-Activating ProteinsSyngap1 protein, mouseautismcortexplasticitysensorySyngap1

Identifiers

PMID34404727
PMCPMC8403968
OpenAlexW3193876487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.