Evidence map›Paper›PMID 34404692›Full record

ArticleGenome research2021

Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in

Moein Rajaei, Ayush Shekhar Saxena, Lindsay M Johnson, Michael C Snyder, Timothy A Crombie, Robyn E Tanny, Erik C Andersen, Joanna Joyner-Matos, Charles F Baer

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  13. Article
  14. Variation in mutational (co)variances.G3 (Bethesda, Md.) · 2023
    Article
  15. Review
  16. Article
  17. Natural variation inGenome research · 2022
    Article
  18. How Can We Resolve Lewontin's Paradox?Genome biology and evolution · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Moein RajaeiDepartment of Biology, University of Florida, Gainesville, Florida 32611, USA.
Ayush Shekhar SaxenaDepartment of Biology, University of Florida, Gainesville, Florida 32611, USA.ORCID 0000-0002-1190-3905
Lindsay M JohnsonDepartment of Biology, University of Florida, Gainesville, Florida 32611, USA.
Michael C SnyderDepartment of Biology, University of Florida, Gainesville, Florida 32611, USA.
Timothy A CrombieDepartment of Biology, University of Florida, Gainesville, Florida 32611, USA.ORCID 0000-0002-5645-4154
Robyn E TannyDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA.ORCID 0000-0002-0611-3909
Erik C AndersenDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA.ORCID 0000-0003-0229-9651
Joanna Joyner-MatosDepartment of Biology, Eastern Washington University, Cheney, Washington 99004, USA.
Charles F BaerDepartment of Biology, University of Florida, Gainesville, Florida 32611, USA.ORCID 0000-0002-0140-5814
University of Florida · USNorthwestern University · USEastern Washington University · US

Funding

100K spontaneous mutations: the foundation for an evolutionary systems biology of C. elegansR01GM127433 · NIGMS · UNIVERSITY OF FLORIDA · PI BAER, CHARLES F, KATJU, VAISHALI · 2018 to 2021
$1.3M
Determination of the distribution of fitness effects of mutations in C. elegansR01GM107227 · NIGMS · UNIVERSITY OF FLORIDA · PI BAER, CHARLES F · 2014 to 2017
$1.1M
NIGMS NIH HHS R01 GM107227NIGMS NIH HHS R01 GM127433
6 · The paper itself

Abstract

Important clues about natural selection can be gleaned from discrepancies between the properties of segregating genetic variants and of mutations accumulated experimentally under minimal selection, provided the mutational process is the same in the laboratory as in nature. The base-substitution spectrum differs between

Indexed as

Caenorhabditis elegansLaboratoriesAllelesAnimalsMutationOxidative Stress

Identifiers

PMID34404692
PMCPMC8415377
OpenAlexW3194751057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.