Evidence map›Paper›PMID 34404606›Full record

Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2022

A Randomized Controlled Trial of Tai Chi Chih or Health Education for Geriatric Depression.

Helen Lavretsky, Michaela M Milillo, Lisa Kilpatrick, Adrienne Grzenda, Pauline Wu, Sarah A Nguyen, Linda M Ercoli, Prabha Siddarth

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02460666 (Brain Connectivity and Response to Tai Chi in Geriatric Depression), which is not on this map. Cited by 28 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 16 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02460666 nacompletednot on this map

Brain Connectivity and Response to Tai Chi in Geriatric Depression

TypeinterventionalSponsorUniversity of California, Los AngelesRan2016 to 2020Enrolled220ConditionsMajor Depressive DisorderArmsTai-Chi-Chih (TCC), Health Education and Wellness Classes (HEW)
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 16 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  20. Inflammatory Markers of Geriatric Depression Response to Tai Chi or Health Education Adjunct Interventions.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Helen LavretskyJane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA. Electronic address: hlavretsky@mednet.ucla.edu.
Michaela M MililloJane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA.
Lisa KilpatrickJane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA.
Adrienne GrzendaJane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA.
Pauline WuJane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA.
Sarah A NguyenJane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA.
Linda M ErcoliJane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA.
Prabha SiddarthJane and Terry Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA.
UCLA Medical Center · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Brain connectivity and response to Tai Chi in geriatric depressionR01AT008383 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2015 to 2019
$4.1M
Mentoring and Research in Translational Science of Integrative MedicineK24AT009198 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Helen Lavretsky · 2016 to 2026
$1.4M
NCATS NIH HHS UL1 TR001881NCCIH NIH HHS K24 AT009198NCCIH NIH HHS R01 AT008383
6 · The paper itself

Abstract

objectivesGeriatric depression is difficult to treat and frequently accompanied by treatment resistance, suicidal ideations and polypharmacy. New adjunctive mind-body treatment strategies can improve clinical outcomes in geriatric depression and reduce risk for side-effects of pharmacological treatments.

methodsWe conducted a 3-month randomized controlled trial to assess the efficacy and tolerability of combining Tai Chi Chih (TCC) or Health Education and Wellness training (HEW) with the stable standard antidepressant treatment on mood and cognitive functioning in depressed older adults (NCT02460666). Primary outcome was change in depression as assessed by the Hamilton Rating Scale for Depression (HAM-D) post-treatment. Remission was defined as HAM-D ≤ 6; naturalistic follow-up continued for 6 months. We also assessed psychological resilience, health-related quality of life and cognition.

resultsOf the 178 randomized participants, 125 completed the 3-month assessment and 117 completed the 6-month assessment. Dropout and tolerability did not differ between groups. Remission rate within TCC was 35.5% and 33.3%, compared to 27.0% and 45.8% in HEW, at 3 and 6 months respectively (χ

conclusionsBoth TCC and HEW combined with a standard antidepressant treatment improved symptoms of depression in older adults. While TCC was superior to HEW in improving general health, we did not find group differences in improvement in mood and cognition.

Indexed as

Tai JiAgedAntidepressive AgentsDepressionHealth EducationHumansQuality of LifeTreatment OutcomeAntidepressive Agents

Identifiers

PMID34404606
PMCPMC10208421
OpenAlexW3187179733

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.