ArticlePilot and feasibility studies2021
Developing an intervention to optimise the outcome of cardiac surgery in people with diabetes: the OCTOPuS pilot study.
Article in Pilot and feasibility studies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Optimising cardiac surgery outcomes in people with diabetes: the OCTOPuS pilot feasibility study.Health technology assessment (Winchester, England) · 2025Article
- Rationale and strategies for improving glycaemic control in diabetic patients undergoing cardiac surgery: a narrative review.Journal of thoracic disease · 2024Review
- Microvascular dysfunction following cardiopulmonary bypass plays a central role in postoperative organ dysfunction.Frontiers in medicine · 2023Review
- Article
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundCardiothoracic surgical outcomes are poorer in people with diabetes compared with those without diabetes. There are two important uncertainties in the management of people with diabetes undergoing major surgery: (1) how to improve diabetes management in the weeks leading up to an elective procedure and (2) whether that improved management leads to improved postoperative outcomes. The aim of this study was to develop and pilot a specialist diabetes team-led intervention to improve surgical outcomes in people with diabetes.
designOpen pilot feasibility study
settingDiabetes and cardiothoracic surgery departments, University Hospital Southampton NHS Foundation Trust
participantsSeventeen people with diabetes undergoing cardiothoracic surgery
interventionFollowing two rapid literature reviews, a prototype intervention was developed based on a previously used nurse-led outpatient intervention and tested. PRIMARY OUTCOME: Feasibility and acceptability of delivering the intervention SECONDARY OUTCOMES: Biomedical data were collected at baseline and prior to surgery. We assessed how the intervention was used. In depth qualitative interviews with participants and healthcare professionals were used to explore perceptions and experiences of the intervention and how it might be improved.
resultsThirteen of the 17 people recruited completed the study and underwent cardiothoracic surgery. All components of the OCTOPuS intervention were used, but not all parts were used for all participants. Minor changes were made to the intervention as a result of feedback from the participants and healthcare professionals. Median (IQR) HbA
conclusionThis study has shown that it is possible to develop a clinical pathway to improve diabetes management prior to admission. The clinical and cost-effectiveness of this intervention will now be tested in a multicentre randomised controlled trial in cardiothoracic centres across the UK.
trial registrationISRCTN; ISRCTN10170306 . Registered 10 May 2018.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.