Observational studyBMC infectious diseases2021
Use of monitoring indicators in hospital management of antimicrobials.
Observational study in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Evaluating antimicrobial resistance and clinical outcomes in surgical ICU using a machine learning perspective: a retrospective observational study.BMC infectious diseases · 2025Observational
- Observational
- Evaluation of standard use of intravenous infusion in 25 general hospitals in Shanxi province based on factor analysis and cluster analysis.Frontiers in pharmacology · 2025Article
- Point Prevalence Survey of Antibiotic Use in Level 1 hospitals in Zambia: Future Prospects for Antimicrobial Stewardship Programs.Infection and drug resistance · 2025Article
- Use of multiple metrics and clustering analysis to assess antimicrobial use in Shanxi hospitals, China: a cross-sectional study based on 25 general hospitals.Frontiers in public health · 2025Article
- Carbapenem use correlates with percentage of patients with COVID-19 in intensive care units.Infection · 2023Article
- Building an antimicrobial stewardship program: A narrative of six years under the Donabedian perspective.Frontiers in pharmacology · 2023Article
- Impact of Antibiotic Consumption on the Acquisition of Extended-Spectrum β-Lactamase ProducingAntibiotics (Basel, Switzerland) · 2022Article
- Educational Activities for Students and Citizens Supporting the One-Health Approach on Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2021Review
- Increased Use of Antibiotics in the Intensive Care Unit During Coronavirus Disease (COVID-19) Pandemic in a Brazilian Hospital.Frontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccording to the literature, 25% to 50% of antimicrobials prescribed in hospitals are unnecessary or inappropriate, directly impacting antimicrobial resistance. Thus, the present study aimed to evaluate the use of antimicrobials in a university hospital in Northeast Brazil, using days of therapy (DOT) and length of therapy (LOT) indicators in accordance with the latest national and international recommendations for monitoring the use of antimicrobials.
methodsThis is an observational, prospective analytical study conducted in a teaching hospital, with 94 active beds, distributed between the intensive care unit (ICU), the surgical clinic (SUR), the medical clinic (MED), the pneumology/infectology department (PNE/INF) and pediatrics (PED). The duration of the study was from the beginning of January to the end of December 2018.
resultsDuring the study period, a total of 11,634 patient-days were followed up and 50.4% of the patients were found to have received some antimicrobial, with a significant reduction in use of 1% per month throughout the year. Patients were receiving antimicrobial therapy for 376 days in every 1000 days of hospitalization (LOT = 376/1000pd). Overall, the 1st-generation cephalosporins and fluoroquinolones were the most used in respect of the number of prescriptions and the duration of therapy. The calculated global DOT/LOT ratio showed that each patient received an average of 1.5 antimicrobials during the hospital stay. The incidence of antimicrobial resistance, globally, for both methicillin-resistant Staphylococcus aureus (methicillin R), Carbapenem-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii (Carbapenem R), was 1 per 1000 patient-days.
conclusionsThe results obtained from the analyses revealed that half of the patients admitted to the hospital who took part in the study were exposed to the use of antimicrobials at some point during their stay. Although moderate, it is noteworthy that there was a decline in the use of antimicrobials throughout the year. The indicators used in this study were found to be very effective for gathering data on the use of antimicrobials, and assessing the results of the initiatives taken as part of the Stewardship program.
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