Evidence map›Paper›PMID 34404330›Full record

ArticleGlobal health action2021

Assessing eligibility for differentiated service delivery, HIV services utilization and virologic outcomes of adult HIV-infected patients in Sierra Leone: a pre-implementation analysis.

Sulaiman Lakoh, Darlinda F Jiba, Alren O Vandy, Eva Poveda, Olukemi Adekanmbi, Mariama J S Murray, Gibrilla F Deen, Foday Sahr, Christopher J Hoffmann, Jeffrey M Jacobson and 2 more

Open access · goldAbstract read
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Article in Global health action, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 6 countries.

Sulaiman LakohDepartment of Medicine, College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.ORCID 0000-0002-7639-0004
Darlinda F JibaMinistry of Health and Sanitation, Freetown, Sierra Leone.
Alren O VandyMinistry of Health and Sanitation, Freetown, Sierra Leone.
Eva PovedaGroup of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS Galicia Sur)-Complexo Hospitalario Universitario De Vigo, SERGAS-UVigo, Spain.ORCID 0000-0003-4835-9875
Olukemi AdekanmbiDepartment of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Mariama J S MurrayMinistry of Health and Sanitation, Freetown, Sierra Leone.
Gibrilla F DeenDepartment of Medicine, College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.
Foday SahrDepartment of Medicine, College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone.
Christopher J HoffmannDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-9422-0519
Jeffrey M JacobsonDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Robert A SalataDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID 0000-0001-8464-0918
George A YendewaDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID 0000-0002-8474-1812
Ministry of Health and Sanitation · SLUniversity of Sierra Leone · SLJohns Hopkins University · USUniversity Hospitals of Cleveland · USGalicia Sur Biomedical Foundation · ESUniversity College Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are limited data to help guide implementation of differentiated HIV service delivery (DSD) in resource-limited settings in sub-Saharan Africa.

objectivesThis pre-implementation study sought to assess the proportion of patients eligible for DSD and HIV services utilization, as well as risk factor analysis of virologic failure in Sierra Leone.

methodsWe conducted a retrospective study of adult HIV-infected patients aged 18 years and older receiving care at the largest HIV treatment center in Sierra Leone 2019-2020. Multiple logistic regression was used to identify predictors of virologic failure.

resultsOf 586 unique patients reviewed, 210 (35.8%) qualified as 'stable' for antiretroviral therapy (ART) delivery. There was high utilization of certain HIV service programs (e.g. HIV status disclosure to partners (83%) and treatment 'buddy' program participation (62.8%)), while other service programs (e.g. partner testing and community HIV support group participation) had low utilization (<50%). Of 429 patients with available viral load, 277 (64.6%) were virologically suppressed. In the multivariate logistic regression analysis of risk factors of virologic failure, CD4 < 350 cells/mm

conclusionApproximately one in three HIV-infected patients on ART were eligible for DSD. We identified gaps in HIV care (i.e. low partner testing, treatment 'buddy', program participation and a substantially high rate of virologic failure) that need to be addressed in preparation for full implementation of DSD in Sierra Leone.

Indexed as

Anti-HIV AgentsHIV InfectionsAdultFacilities and Services UtilizationHumansRetrospective StudiesSierra LeoneViral LoadAnti-HIV Agentsdifferentiated careHIVimplementationresource-limited settingsSierra Leone

Identifiers

PMID34404330
PMCPMC8381912
OpenAlexW3193861828

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.