Evidence map›Paper›PMID 34404317›Full record

ArticleNeurocase2022

Tonal and orthographic analysis in a Cantonese-speaking individual with nonfluent/agrammatic variant primary progressive aphasia.

Boon Lead Tee, Jessica Deleon, Lorinda Kwan Chen Li Ying, Bruce L Miller, Raymond Y Lo, Eduardo Europa, Swati Sudarsan, Stephanie Grasso, Maria Luisa Gorno-Tempini

Open access · greenAbstract readCase Reports
In one paragraph

Article in Neurocase, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities-focused research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Boon Lead TeeMemory and Aging Center, University of California at San Francisco, San Francisco, CA, United States.ORCID 0000-0003-2217-3466
Jessica DeleonMemory and Aging Center, University of California at San Francisco, San Francisco, CA, United States.
Lorinda Kwan Chen Li YingDepartment of Special Education and Counselling, The Education University of Hong Kong, Hong Kong, China.
Bruce L MillerMemory and Aging Center, University of California at San Francisco, San Francisco, CA, United States.
Raymond Y LoDepartment of Neurology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.
Eduardo EuropaMemory and Aging Center, University of California at San Francisco, San Francisco, CA, United States.
Swati SudarsanMemory and Aging Center, University of California at San Francisco, San Francisco, CA, United States.
Stephanie GrassoThe Aphasia Research and Treatment Lab, Department of Communication Sciences and Disorders, The University of Texas, Austin, United States.
Maria Luisa Gorno-TempiniMemory and Aging Center, University of California at San Francisco, San Francisco, CA, United States.
University of California, San Francisco · USUniversity Memory and Aging Center · USBuddhist Tzu Chi General Hospital · TWEducation University of Hong Kong · HKThe University of Texas at Austin · USTzu Chi University · TW

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, YADONG · 2004 to 2018
$27.1M
The Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1M
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Training - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4M
Connectomic imaging in familial and sporadic frontotemporal degenerationU01AG052943 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GORNO TEMPINI, MARIA LUISA, GROSSMAN, MURRAY · 2016 to 2019
$5.9M
Establishing Evidence-based Treatment for Speech and Language in Primary Progressive AphasiaR01DC016291 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI HENRY, MAYA · 2017 to 2021
$3.3M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Primary Progressive Aphasia: Beyond the Clinical VariantsK23DC018021 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DELEON, JESSICA ANNE · 2020 to 2024
$995k
Chinese Language Assessment in Primary Progressive AphasiaR21AG068757 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2021 to 2022
$360k
NIA NIH HHS P01 AG019724NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG038791NIA NIH HHS R21 AG068757NIA NIH HHS U01 AG045390NIA NIH HHS U01 AG052943NIDCD NIH HHS K23 DC018021NIDCD NIH HHS K24 DC015544NIDCD NIH HHS R01 DC016291NINDS NIH HHS R01 NS050915NINDS NIH HHS U54 NS092089
6 · The paper itself

Abstract

Clinical understanding of primary progressive aphasia (PPA) has been established based on English-speaking population. The lack of linguistic diversity in research hinders the diagnosis of PPA in non-English speaking patients. This case report describes the tonal and orthographic deficits of a multilingual native Cantonese-speaking woman with nonfluent/agrammatic variant PPA (nfvPPA) and progressive supranuclear palsy. Our findings suggest that Cantonese-speaking nfvPPA patients exhibit tone production impairments, tone perception deficits at the lexical selection processing, and linguistic dysgraphia errors unique to logographic script writer. These findings suggest that linguistic tailored approaches offer novel and effective tools in identifying non-English speaking PPA individuals.

Indexed as

AgraphiaAphasia, Primary ProgressivePrimary Progressive Nonfluent AphasiaSupranuclear Palsy, ProgressiveFemaleHumanslogographic scriptorthographyPrimary progressive aphasiatone

Identifiers

PMID34404317
PMCPMC9345301
OpenAlexW3193429463

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.