Evidence map›Paper›PMID 34404315›Full record

ArticleAdipocyte2021

Hematopoietic stem cells produce intermediate lineage adipocyte progenitors that simultaneously express both myeloid and mesenchymal lineage markers in adipose tissue.

Kathleen M Gavin, Timothy M Sullivan, Joanne K Maltzahn, Jeremy T Rahkola, Alistair S Acosta, Wendy M Kohrt, Susan M Majka, Dwight J Klemm

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Adipocyte, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Macrophages and Bone Remodeling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Kathleen M GavinEastern Colorado Veterans Administration Geriatric Research, Education and Clinical Center (GRECC), Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.
Timothy M SullivanEastern Colorado Veterans Administration Geriatric Research, Education and Clinical Center (GRECC), Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.
Joanne K MaltzahnEastern Colorado Veterans Administration Geriatric Research, Education and Clinical Center (GRECC), Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.
Jeremy T RahkolaDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.
Alistair S AcostaFlow Cytometry Shared Resource, University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Wendy M KohrtEastern Colorado Veterans Administration Geriatric Research, Education and Clinical Center (GRECC), Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.
Susan M MajkaCardiovascular Pulmonary Research Laboratory, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Dwight J KlemmEastern Colorado Veterans Administration Geriatric Research, Education and Clinical Center (GRECC), Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.
Geriatric Research Education and Clinical Center · USUniversity of Colorado Anschutz Medical Campus · USNational Jewish Health · USUniversity of Colorado Cancer Center · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Suppression of ERalpha in Hematopoietic Stem Cell-Derived Adipocytes Increases Adiposity via Kynurenine and the Aryl Hydrocarbon ReceptorU54AG062319 · NIA · UNIVERSITY OF COLORADO DENVER · PI Paul S. Maclean · 2018 to 2026
$13.5M
Integrin signaling promotes production of adipocytes from hematopoietic cellsR01DK109547 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI KLEMM, DWIGHT J · 2016 to 2019
$1.4M
Sex differences in adipogenic potential of adipose tissue myeloid cells in humansK01DK109053 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI GAVIN, KATHLEEN MARIE · 2016 to 2020
$724k
Diminished Sex Hormone Levels Stimulate Production of Inflammatory Bone Marrow-Derived AdipocytesI01BX005135 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI KLEMM, DWIGHT J · 2021 to 2024
–
BLRD VA I01 BX005135NCATS NIH HHS UL1 TR001082NCI NIH HHS P30 CA046934NIA NIH HHS U54 AG062319NIDDK NIH HHS K01 DK109053NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK109547
6 · The paper itself

Abstract

Some adipocytes are produced from bone marrow hematopoietic stem cells.

Indexed as

AdipocytesBone Marrow CellsAdipose TissueAnimalsCell DifferentiationHematopoietic Stem CellsMiceAdipocytehaematopoietic stem cellmesenchymalmyeloidprogenitor

Identifiers

PMID34404315
PMCPMC8381847
OpenAlexW3195218877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.