ArticleNeuroImage2021
Decompose quantitative susceptibility mapping (QSM) to sub-voxel diamagnetic and paramagnetic components based on gradient-echo MRI data.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed.
- A Realistic In Silico Brain Phantom for Quantifying Susceptibility Anisotropy-Induced Error in Susceptibility Separation.Magnetic resonance in medicine · 2026Article
- One-Year Substantia NigraMovement disorders : official journal of the Movement Disorder Society · 2026Article
- Susceptibility Source Separation Unveils Paramagnetic and Diamagnetic Trajectories in Healthy Brains From 5 to 90 Years.NMR in biomedicine · 2026Article
- Sub-voxel QSM reveals the mechanism linking substantia nigra iron and temporal diamagnetism to PD gait.NPJ Parkinson's disease · 2026Article
- Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism.Annals of clinical and translational neurology · 2026Article
- Detecting early brain susceptibility changes before demyelination in cuprizone mouse model using quantitative susceptibility mapping (QSM).NeuroImage · 2026Article
- Technical Feasibility of Quantitative Susceptibility Mapping Radiomics for Predicting Deep Brain Stimulation Outcomes in Parkinson Disease.Neurosurgery · 2026Article
- Assessing Age-Associated Influences on Paramagnetic and Diamagnetic Susceptibility Maps in Postmortem Human Brains.NMR in biomedicine · 2026Article
- Temperature Dependence of Paramagnetic Species in the Human Brain Tissue: An X-Band EPR Study.Magnetic resonance in medicine · 2026Article
- Detecting Beta-Amyloid Plaque via Low Rank Based Orthogonal Projection and Spatial-Spectrum Detector Using High-Resolution Quantitative Susceptibility Mapping for Preclinical Studies.IEEE transactions on bio-medical engineering · 2026Article
- Axonal microstructure and compartmentalization impact the orientation and time dependence of mesoscopic transverse relaxation.Scientific reports · 2026Article
- Mapping Intracellular Volume Fraction With Susceptibility Source Decomposition as a Marker for Tissue Cellularity.Journal of magnetic resonance imaging : JMRI · 2026Article
- Quantitative susceptibility mapping reveals differences between subtypes of Lewy body dementia.Brain : a journal of neurology · 2026Article
- Exploring the role of quantitative susceptibility mapping in assessing brain iron deposition in hemodialysis patients.Insights into imaging · 2026Article
- Voxel-Wise Whole-Brain Analysis in Quantitative Susceptibility Mapping: A Narrative Review.Human brain mapping · 2026Review
- Repeatability of Susceptibility Source Separation Methods in Human Brain: A Single-Site Study at 3 T.NMR in biomedicine · 2026Article
- Quantitative susceptibility mapping demonstrates ageing-related long-term structural brain changes in adult rats after mild ischaemic stroke.Brain communications · 2026Article
- Thalamic quantitative susceptibility mapping and susceptibility source separation: a critical narrative review of evidence and interpretation.Frontiers in neurology · 2026Review
- Vessel segmentation forMagnetic resonance in medicine · 2026Article
- Importance of RMagnetic resonance in medicine · 2026Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeA method named DECOMPOSE-QSM is developed to decompose bulk susceptibility measured with QSM into sub-voxel paramagnetic and diamagnetic components based on a three-pool complex signal model.
methodsMulti-echo gradient echo signal is modeled as a summation of three weighted exponentials corresponding to three types of susceptibility sources: reference susceptibility, diamagnetic and paramagnetic susceptibility relative to the reference. Paramagnetic component susceptibility (PCS) and diamagnetic component susceptibility (DCS) maps are constructed to represent the sub-voxel compartments by solving for linear and nonlinear parameters in the model.
resultsNumerical forward simulation and phantom validation confirmed the ability of DECOMPOSE-QSM to separate the mixture of paramagnetic and diamagnetic components. The PCS obtained from temperature-variant brainstem imaging follows the Curie's Law, which further validated the model and the solver. Initial in vivo investigation of human brain images showed the ability to extract sub-voxel PCS and DCS sources that produce visually enhanced contrast between brain structures comparing to threshold QSM.
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Registered trials
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