Evidence map›Paper›PMID 34403529›Full record

ReviewAmerican journal of primatology2021

Nonhuman primates at the intersection of aging biology, chronic disease, and health: An introduction to the American Journal of Primatology Special Issue on aging, cognitive decline, and neuropathology in nonhuman primates.

Carol A Shively, Agnès Lacreuse, Brett M Frye, Emily S Rothwell, Manuel Moro

Open access · greenAbstract readReview
In one paragraph

Review in American journal of primatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Biomarkers of ageing of humans and non-human primates.Nature reviews. Molecular cell biology · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Carol A ShivelyDepartment of Pathology/Comparative Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.ORCID 0000-0002-1536-2288
Agnès LacreuseDepartment of Psychological and Brain Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, USA.ORCID 0000-0003-2890-9649
Brett M FryeDepartment of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.ORCID 0000-0001-8818-063X
Emily S RothwellDepartment of Psychological and Brain Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, USA.ORCID 0000-0002-7791-2695
Manuel MoroDivision of Aging Biology, National Institute on Aging, National Institutes of Health, Maryland, USA.
University of Massachusetts Amherst · USWake Forest University · USNational Institutes of Health · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Vervet Research Colony as a Biomedical ResourceP40OD010965 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Matthew Jorgensen · 2012 to 2026
$14.6M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ESPELAND, MARK ANDREW · 2016 to 2020
$12.2M
Development of an Innovative Vervet (Chlorocebus aethiops sabaeus) Model of Early Alzheimer's-like Neuropathology and SymptomatologyR24AG073199 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CRAFT, SUZANNE, SHIVELY, CAROL A. · 2021 to 2024
$5.6M
Translational Training in Aging and Alzheimer’s Disease Related DisordersT32AG033534 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI STEPHEN B. KRITCHEVSKY · 2009 to 2026
$3.6M
Effects of Western and Mediterranean Diets on Metabolic and Neuropathologic Risk Factors for Alzheimer's Disease in Nonhuman PrimatesRF1AG058829 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CRAFT, SUZANNE, SHIVELY, CAROL A. · 2018 to 2018
$2.8M
Sex differences in cognitive and brain aging: a primate modelR01AG046266 · NIA · UNIVERSITY OF MASSACHUSETTS AMHERST · PI LACREUSE, AGNES · 2014 to 2018
$2.1M
Behavioral and Neural Indicators of Prodromal Alzheimer's DiseaseF32AG064925 · NIA · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTHWELL, EMILY S. · 2019 to 2023
$190k
NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1TR001420NIA NIH HHS F32 AG064925NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG21332NIA NIH HHS R01 AG046266NIA NIH HHS R24 AG073199NIA NIH HHS RF1 AG058829NIA NIH HHS T32 AG033534NIH HHS P40 OD010965ODCDC CDC HHS P40 OD010965
6 · The paper itself

Abstract

Aging across the Primate Order is poorly understood because ages of individuals are often unknown, there is a dearth of aged animals available for study, and because aging is best characterized by longitudinal studies which are difficult to carry out in long-lived species. The human population is aging rapidly, and advanced age is a primary risk factor for several chronic diseases and conditions that impact healthspan. As lifespan has increased, diseases and disorders of the central nervous system (CNS) have become more prevalent, and Alzheimer's disease and related dementias have become epidemic. Nonhuman primate (NHP) models are key to understanding the aging primate CNS. This Special Issue presents a review of current knowledge about NHP CNS aging across the Primate Order. Similarities and differences to human aging, and their implications for the validity of NHP models of aging are considered. Topics include aging-related brain structure and function, neuropathologies, cognitive performance, social behavior and social network characteristics, and physical, sensory, and motor function. Challenges to primate CNS aging research are discussed. Together, this collection of articles demonstrates the value of studying aging in a breadth of NHP models to advance our understanding of human and nonhuman primate aging and healthspan.

Indexed as

Cognitive DysfunctionPrimatesAgingAnimalsBiologyChronic DiseaseUnited StatesagingAlzheimer's diseasecognitive declinegait speednonhuman primate

Identifiers

PMID34403529
PMCPMC8935964
OpenAlexW3193871536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.