Evidence map›Paper›PMID 34403090›Full record

ArticleCurrent medical science2021

Molecular Mediators of Estrogen Reduction-induced Otolith Shedding.

Mei-Yan Feng, Huan-Huan Gu, Qing Tian, Hua-Lan Yang, Jian-Hua Zhuang

Abstract read
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Article in Current medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Mei-Yan Feng *Department of Neurology, Medical Center for Vertigo and Balance Disorders, Shanghai Changzheng Hospital of Navy Medical University, Shanghai, 200003, China.
Huan-Huan Gu *Department of Neurology, Medical Center for Vertigo and Balance Disorders, Shanghai Changzheng Hospital of Navy Medical University, Shanghai, 200003, China.
Qing TianDepartment of Neurology, Medical Center for Vertigo and Balance Disorders, Shanghai Changzheng Hospital of Navy Medical University, Shanghai, 200003, China.
Hua-Lan YangDepartment of Neurology, Medical Center for Vertigo and Balance Disorders, Shanghai Changzheng Hospital of Navy Medical University, Shanghai, 200003, China. yanghualan66@163.com.
Jian-Hua ZhuangDepartment of Neurology, Medical Center for Vertigo and Balance Disorders, Shanghai Changzheng Hospital of Navy Medical University, Shanghai, 200003, China. jianhuazh11@126.com.
Shanghai Changzheng Hospital · CNFudan University · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePrevious study suggested that estradiol (E2) plays an important role in otolith shedding by regulating the expression of otoconin 90 (OC90). The purpose of this article is to provide further data on the effect and mechanism of E2 on the morphology of otolith.

methodsThe rats receiving bilateral ovariectomy (OVX) were used as animal models. Co-immunoprecipitation was used to observe the relationship between estrogen receptor (ER) and estrogen-related receptor α (ERRα). The morphology of otolith was observed under the scanning electron microscopy. Western blotting and qPCR were used for quantitative analysis of the roles of ER and ERRα in regulating OC90 expression.

resultsThe looser otoliths were observed in rats receiving bilateral OVX, which could be reversed by supplementation with E2. The level of ERRα was decreased in bilateral OVX rats. ER and ERRα interacted with each other on the regulation of the expression of OC90.

conclusionOur results suggest ER and ERRα are both important downstream receptors involved in regulating OC90 expression in utricles of rats, and ERRα probably functions by interacting with ER. This provides evidence for the mechanism of otolith shedding. And it may be significant for future studies of targeted prevention and therapies for benign paroxysmal positional vertigo.

Indexed as

AnimalsCalcium-Binding ProteinsERRalpha Estrogen-Related ReceptorEstradiolEstrogensFemaleHumansOtolithic MembraneOvariectomyRatsReceptors, EstrogenCalcium-Binding ProteinsERRalpha Estrogen-Related ReceptorEstradiolEstrogensOC90 protein, humanReceptors, Estrogenbenign paroxysmal positional vertigoestrogen receptorestrogen-related receptor αotoconin 90otolith

Identifiers

PMID34403090
OpenAlexW3195891673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.