Evidence map›Paper›PMID 34402985›Full record

ArticleTropical animal health and production2021

Complete genome analysis of African swine fever virus responsible for outbreaks in domestic pigs in 2018 in Burundi and 2019 in Malawi.

Jean N Hakizimana, Jean B Ntirandekura, Clara Yona, Lionel Nyabongo, Gladson Kamwendo, Julius L C Chulu, Désiré Ntakirutimana, Olivier Kamana, Hans Nauwynck, Gerald Misinzo

Open access · hybridAbstract read
In one paragraph

Article in Tropical animal health and production, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 6 countries.

Jean N HakizimanaSACIDS Africa Centre of Excellence for Infectious Diseases, SACIDS Foundation for One Health, Sokoine University of Agriculture, PO Box 3297, Morogoro, Tanzania.
Jean B NtirandekuraDepartment of Animal Health and Productions, University of Burundi, PO Box 1550, Bujumbura, Burundi.
Clara YonaSACIDS Africa Centre of Excellence for Infectious Diseases, SACIDS Foundation for One Health, Sokoine University of Agriculture, PO Box 3297, Morogoro, Tanzania.
Lionel NyabongoNational Veterinary Laboratory of Burundi, PO Box 227, Bujumbura, Burundi.
Gladson KamwendoDepartment of Animal Health and Livestock Development, Ministry of Agriculture, Irrigation and Water Development, PO Box 2096, Lilongwe, Malawi.
Julius L C ChuluDepartment of Animal Health and Livestock Development, Ministry of Agriculture, Irrigation and Water Development, PO Box 2096, Lilongwe, Malawi.
Désiré NtakirutimanaNational Veterinary Laboratory of Burundi, PO Box 227, Bujumbura, Burundi.
Olivier KamanaDepartment of Applied Research and Development and Foresight Incubation, National Industrial Research and Development Agency, PO Box 273, Kigali, Rwanda.
Hans NauwynckLaboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.
Gerald MisinzoSACIDS Africa Centre of Excellence for Infectious Diseases, SACIDS Foundation for One Health, Sokoine University of Agriculture, PO Box 3297, Morogoro, Tanzania. gerald.misinzo@sacids.org.ORCID http://orcid.org/0000-0003-1827-6403
Southern African Centre for Infectious Disease Surveillance · TZUniversité du Burundi · BIMalawi Government · MWGhent University · BENational Science and Technology Development Agency · TH

Funding

International Foundation for Science B_6269-1
6 · The paper itself

Abstract

Several African swine fever (ASF) outbreaks in domestic pigs have been reported in Burundi and Malawi and whole-genome sequences of circulating outbreak viruses in these countries are limited. In the present study, complete genome sequences of ASF viruses (ASFV) that caused the 2018 outbreak in Burundi (BUR/18/Rutana) and the 2019 outbreak in Malawi (MAL/19/Karonga) were produced using Illumina next-generation sequencing (NGS) platform and compared with other previously described ASFV complete genomes. The complete nucleotide sequences of BUR/18/Rutana and MAL/19/Karonga were 176,564 and 183,325 base pairs long with GC content of 38.62 and 38.48%, respectively. The MAL/19/Karonga virus had a total of 186 open reading frames (ORFs) while the BUR/18/Rutana strain had 151 ORFs. After comparative genomic analysis, the MAL/19/Karonga virus showed greater than 99% nucleotide identity with other complete nucleotides sequences of p72 genotype II viruses previously described in Tanzania, Europe and Asia including the Georgia 2007/1 isolate. The Burundian ASFV BUR/18/Rutana exhibited 98.95 to 99.34% nucleotide identity with genotype X ASFV previously described in Kenya and in Democratic Republic of the Congo (DRC). The serotyping results classified the BUR/18/Rutana and MAL/19/Karonga ASFV strains in serogroups 7 and 8, respectively. The results of this study provide insight into the genetic structure and antigenic diversity of ASFV strains circulating in Burundi and Malawi. This is important in order to understand the transmission dynamics and genetic evolution of ASFV in eastern Africa, with an ultimate goal of designing an efficient risk management strategy against ASF transboundary spread.

Indexed as

African Swine FeverAfrican Swine Fever VirusSwine DiseasesAnimalsBurundiDisease OutbreaksMalawiPhylogenySus scrofaSwineTanzaniaAfrican swine fever virusAsfarviridaeBurundiDomestic pigMalawiWhole-genome sequencing

Identifiers

PMID34402985
PMCPMC8368048
OpenAlexW3195748507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.