SynthesisBrain and behavior2021
Systematic review and meta-analysis identify significant relationships between clinical anxiety and lower urinary tract symptoms.
Synthesis in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis identify significant relationships between clinical anxiety and lower urinary tract symptoms.Brain and behavior · 2021Pooled it
- Flupentixol/melitracen for epigastric pain syndrome in female patients with abnormal urinalysis and therapeutic insights into the brain-bladder axis.Scientific reports · 2025Trial
- Ecological Momentary Assessment Reveals Greater Anxiety and Marked Instability of Urinary Urgency in Overactive Bladder.International urogynecology journal · 2026Article
- Clinical Factors Associated with Anxiety Disorders in Adults with Childhood Hypospadias Repair: Results from the F.R.E.S.H. Study.Journal of personalized medicine · 2026Article
- Urgency warning time and urgency frequency represent distinct dimensions of urinary urgency: a nationwide study from the Japan Community Health Survey 2023.World journal of urology · 2026Article
- Association between mental disorder and hospitalization outcomes in neurogenic bladder: a retrospective nationwide inpatient sample database study.International urology and nephrology · 2026Article
- Piezo2 in sensory neurons contributes to inflammation-induced bladder overactivity and is associated with the effects of electroacupuncture.Frontiers in neuroscience · 2026Article
- Psychological and Behavioral Contributors to Lower Urinary Tract Dysfunction: Trauma, Stress, and Neurobiological Pathways.Current bladder dysfunction reports · 2026Review
- Article
- Polycystic ovary syndrome negatively affects sexual function and lower urinary tract symptoms in syrian women: a case-control study.Scientific reports · 2025Article
- Lower Urinary Tract Symptoms in Mental Illness: A Topic Modeling Approach to Online Mental Health Communities.International neurourology journal · 2024Article
- Rapid Lifestyle Recommendations to Improve Urologic, Heart and Overall Health.Current urology reports · 2024Review
- The relationship between depression, anxiety and lower urinary tract symptoms in men.Prostate international · 2024Article
- A pilot study on the potential of photobiomodulation to safely modify symptoms of an overactive bladder.Bladder (San Francisco, Calif.) · 2024Article
- The Need for Prospective Cohort Study of the Association between Lower Urinary Tract Symptoms and Cognitive Decline in Elderly Individuals.The world journal of men's health · 2023Article
- Should Psychiatric Symptoms Be Evaluated in Elderly Males With Lower Urinary Tract Symptoms?International neurourology journal · 2023Article
- Why Are Some People with Lower Urinary Tract Symptoms (LUTS) Depressed? New Evidence That Peripheral Inflammation in the Bladder Causes Central Inflammation and Mood Disorders.International journal of molecular sciences · 2023Review
- Lower Urinary Tract Symptoms in Depression: A Review.Health psychology research · 2023Article
- Association between sodium or salt intake and lower urinary tract symptoms: a systematic review.Therapeutic advances in urologyReview
- The Effect of Intravesical Injection of Botulinum Toxin A (BTX-A) on Quality of Life of Pediatrics Diagnosed With Overactive Bladder: A Quasi-Experimental Study.Sage open pediatricsArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLower urinary tract symptoms (LUTS), such as voiding symptoms, overactive bladder, and interstitial cystitis, and anxiety disorders are often comorbid conditions in patients. However, the existing evidence regarding the rates and nature of the co-occurrence of these conditions has not been systematically evaluated. The aim of this study was to examine these relationships.
methodsWe conducted a systematic review and meta-analysis to examine the relationship between LUTS and anxiety. We searched for articles published from January 1990 to July 2019 in PubMed, CENTRAL, PsycINFO, and Google Scholar. Outcomes were anxiety-related disorders and symptoms (clinically significant anxiety) and LUTS. We performed random-effects meta-analyses, inspected funnel plots, and applied the Egger's test to evaluate publication bias. We followed PRISMA guidelines and recorded our protocol on PROSPERO (ID = CRD42019118607).
resultsWe identified 814 articles, of which 94 fulfilled inclusion criteria, and 23 had sufficient data for meta-analysis. The odds ratio (OR) for clinically significant anxiety among individuals with LUTS was 2.87 (95% CI: 2.38,3.46, p < .001). The OR for LUTS among individuals with clinically significant anxiety was 2.87 (95% CI: 1.07,7.74, p < .001), although very few studies examined this relationship. A large value of I
conclusionThe results demonstrate a significant association between clinically significant anxiety and LUTS in both females and males. There were limited studies on younger individuals and on individuals ascertained for clinically significant anxiety, which should motivate further study in these areas. Understanding the co-occurrence of these conditions will lead to better prevention and interventions to ameliorate the progression of the symptoms and improve the quality of life. A thorough assessment of anxiety may provide more optimal care for LUTS patients.
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